Absolute configurations of new cembrane-type diterpenoids from the Hainan soft coral Sarcophyton crassocaule

doi:10.1016/j.tetlet.2020.152008

	Absolute configurations of new cembrane-type diterpenoids from the Hainan soft coral Sarcophyton crassocaule
	Ye, Fei 2,3; Gu, Yu-Cheng 1; Guo, Yue-Wei 2,3,4; Li, Xu-Wen 2,3,4
刊名	TETRAHEDRON LETTERS
	2020-06-18
卷号	61 期号:25 页码:4
关键词	Soft coral Sarcophyton Cembranoids Absolute configuration
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2020.152008
通讯作者	Guo, Yue-Wei(ywguo@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn)
英文摘要	The determination of the stereochemistry of cembrane type diterpenoids is always a challenging task due to the flexibility of the 14-membered macrocycle. In this paper, three new cembranoids, ximaocembrols A-C (1-3), were isolated from the Hainan soft coral Sarcophyton crassocaule, and ximaocembrol C was further separated by chiral HPLC to its corresponding enantiomers (+/-)-3, respectively. The absolute configurations of these new compounds were successfully elucidated by using a series of reliable approaches, including extensive spectroscopic analysis, TDDFT-ECD calculation, modified Mosher's method, and Snatzke's method. (C) 2020 Elsevier Ltd. All rights reserved.
资助项目	National Key Research and Development Program of China[2018YFC0310903] ; Natural Science Foundation of China[81991521] ; NSFC/CNRS joint project[81811530284] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Chinese Academy of Sciences[2016258] ; SA-SIBS Scholarship Program ; Syngenta-SIMM-PhD Studentship Project
WOS关键词	MO-2(OAC)(4)
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000537694300009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291613]
专题	中国科学院上海药物研究所
通讯作者	Guo, Yue-Wei; Li, Xu-Wen
作者单位	1.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhaniang Hitech Pk, Shanghai 201203, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Ye, Fei,Gu, Yu-Cheng,Guo, Yue-Wei,et al. Absolute configurations of new cembrane-type diterpenoids from the Hainan soft coral Sarcophyton crassocaule[J]. TETRAHEDRON LETTERS,2020,61(25):4.
APA	Ye, Fei,Gu, Yu-Cheng,Guo, Yue-Wei,&Li, Xu-Wen.(2020).Absolute configurations of new cembrane-type diterpenoids from the Hainan soft coral Sarcophyton crassocaule.TETRAHEDRON LETTERS,61(25),4.
MLA	Ye, Fei,et al."Absolute configurations of new cembrane-type diterpenoids from the Hainan soft coral Sarcophyton crassocaule".TETRAHEDRON LETTERS 61.25(2020):4.