Oxidative -Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins

doi:10.1055/s-0037-1610385

	Oxidative -Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins
	Ai, Lingsheng 1; Wang, Weijin 1; Wei, Jialiang 1; Li, Qing 1; Song, Song 1,2; Jiao, Ning 1,2
刊名	SYNLETT
	2019-03-01
卷号	30 期号:4 页码:437-441
关键词	halogenation alcohols dimethyl sulfoxide halohydrins oxidation
ISSN号	0936-5214
DOI	10.1055/s-0037-1610385
通讯作者	Song, Song(ssong@bjmu.edu.cn) ; Jiao, Ning(jiaoning@pku.edu.cn)
英文摘要	beta-Halohydrins bearing transformable halo- and hydroxyl groups, are easily converted into various valuable blocks in organic and pharmaceutical synthesis. A diastereoselective -halogenation of benzylic alcohols was achieved under simple and low-cost conditions, which provided a direct synthesis of -halohydrins. The simple reaction conditions, easily available reagents, high diastereoselectivities, and additional oxidant-free make this reaction very attractive and practical.
资助项目	National Basic Research Program of China (973 Program)[2015CB856600] ; National Natural Science Foundation of China[21602005] ; National Natural Science Foundation of China[21632001] ; National Natural Science Foundation of China[21772002] ; State Key Laboratory of Drug Research
WOS关键词	LAYERED DOUBLE HYDROXIDES ; C-H BONDS ; DIMETHYL-SULFOXIDE ; METHYL KETONES ; C(SP(3))-H FUNCTIONALIZATION ; CATALYTIC FUNCTIONALIZATION ; AROMATIC-COMPOUNDS ; MOLECULAR-OXYGEN ; FACILE SYNTHESIS ; BROMINATION
WOS研究方向	Chemistry
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000459590400016
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290409]
专题	中国科学院上海药物研究所
通讯作者	Song, Song; Jiao, Ning
作者单位	1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Xue Yuan Rd 38, Beijing 100191, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Ai, Lingsheng,Wang, Weijin,Wei, Jialiang,et al. Oxidative -Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins[J]. SYNLETT,2019,30(4):437-441.
APA	Ai, Lingsheng,Wang, Weijin,Wei, Jialiang,Li, Qing,Song, Song,&Jiao, Ning.(2019).Oxidative -Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins.SYNLETT,30(4),437-441.
MLA	Ai, Lingsheng,et al."Oxidative -Halogenation of Alcohols: A Concise and Diastereoselective Approach to Halohydrins".SYNLETT 30.4(2019):437-441.