Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds

doi:10.1039/c9qo00324j

	Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds
	Peng, Xiaofeng 1,2; Zhang, Xiaofei 1; Li, Shunyao 1,2; Lu, Yunfu 1,2; Lan, Lefu 1,2; Yang, Chunhao 1,2
刊名	ORGANIC CHEMISTRY FRONTIERS
	2019-06-07
卷号	6 期号:11 页码:1775-1779
ISSN号	2052-4129
DOI	10.1039/c9qo00324j
通讯作者	Lan, Lefu(llan@simm.ac.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要	Herein, a simple and regioselective synthesis of (2-hydroxyphenyl)(3-(trifluoromethyl/ cyano/ phosphonate)- 1H-pyrazol-5-yl) methanones as pyrrolomycin analogues was reported. This reaction could proceed from 3-formylchromones and the corresponding diazo compounds by a silver-mediated one-pot cascade reaction under mild conditions with a broad substrate scope. Most of all, some products displayed potent antibacterial activities.
资助项目	Science and Technology Commission of Shanghai Municipality[18431907100] ; Shanghai Sailing Program[17YF1423400]
WOS关键词	REGIOSELECTIVE SYNTHESIS ; BIOLOGICAL EVALUATION ; INSECTICIDAL CHLORFENAPYR ; DESIGN ; CYCLOADDITION ; FLUORINE ; FLOW
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000469257000004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289638]
专题	中国科学院上海药物研究所
通讯作者	Lan, Lefu; Yang, Chunhao
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Peng, Xiaofeng,Zhang, Xiaofei,Li, Shunyao,et al. Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds[J]. ORGANIC CHEMISTRY FRONTIERS,2019,6(11):1775-1779.
APA	Peng, Xiaofeng,Zhang, Xiaofei,Li, Shunyao,Lu, Yunfu,Lan, Lefu,&Yang, Chunhao.(2019).Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds.ORGANIC CHEMISTRY FRONTIERS,6(11),1775-1779.
MLA	Peng, Xiaofeng,et al."Silver-mediated synthesis of novel 3-CF3/CN/phosphonate-substituted pyrazoles as pyrrolomycin analogues from 3-formylchromones and diazo compounds".ORGANIC CHEMISTRY FRONTIERS 6.11(2019):1775-1779.