Indole alkaloid glycosides from Isatis tinctoria roots

doi:10.1080/14786419.2019.1624960

	Indole alkaloid glycosides from Isatis tinctoria roots
	Zhang, Dongdong 1; Du, Kang 1; Zhao, Yitian 1; Shi, Songshan 2; Wu, Yingchun 1; Jia, Qi 1; Chen, Kaixian 1,3; Li, Yiming 1; Wang, Rui 1
刊名	NATURAL PRODUCT RESEARCH
	2019-06-04
页码	7
关键词	Isatis tinctoria indole alkaloid glycosides structure determination anti-inflammatory activity
ISSN号	1478-6419
DOI	10.1080/14786419.2019.1624960
通讯作者	Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn)
英文摘要	Isatindigoside A and B (1 - 2), two new indole alkaloid glycosides along with five known ones (3 - 7) were obtained from the roots of I. tinctoria. Their structures were determined as isatindigoside A (1), isatindigoside B (2), isatindosulfonicacid A 3-O-beta-D-glucopyranoside (3), indole-3-acetonitrile 6-O-beta-D-glucopyranoside (4), isatindigobisindoloside A (5), isatindigobisindoloside B (6) isatindigobisindoloside F (7), by physicochemical properties and spectroscopic methods including 1 D, 2 D NMR, IR, HR-ESI-MS data. Nitric oxide (NO) inhibitory activities of all of the isolated compounds (1 - 7) were also evaluated. Compounds 2 and 7 showed inhibitory effects against LPS-stimulated RAW 264.7 cells with IC50 values of 27.6 mu M and 18.8 mu M, respectively. [GRAPHICS] .
资助项目	National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; High level University Innovation Team ; Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine
WOS关键词	INDIGOTICA
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000472361100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289552]
专题	中国科学院上海药物研究所
通讯作者	Li, Yiming; Wang, Rui
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Dongdong,Du, Kang,Zhao, Yitian,et al. Indole alkaloid glycosides from Isatis tinctoria roots[J]. NATURAL PRODUCT RESEARCH,2019:7.
APA	Zhang, Dongdong.,Du, Kang.,Zhao, Yitian.,Shi, Songshan.,Wu, Yingchun.,...&Wang, Rui.(2019).Indole alkaloid glycosides from Isatis tinctoria roots.NATURAL PRODUCT RESEARCH,7.
MLA	Zhang, Dongdong,et al."Indole alkaloid glycosides from Isatis tinctoria roots".NATURAL PRODUCT RESEARCH (2019):7.