N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles

doi:10.1002/anie.201907188

	N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles
	Zhang, Zi-Jing 1,2; Zhang, Ling 1,2; Geng, Rui-Long 1,2; Song, Jin 1,2; Chen, Xiao-Hua 3; Gong, Liu-Zhu 1,2,4
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2019-07-24
页码	6
关键词	cooperative catalysis copper enals N-heterocyclic carbenes spirooxindoles
ISSN号	1433-7851
DOI	10.1002/anie.201907188
通讯作者	Song, Jin(jill@ustc.edu.cn) ; Gong, Liu-Zhu(gonglz@ustc.edu.cn)
英文摘要	Highly enantioselective [3+3] and [3+4] annulations of isatin-derived enals with ethynylethylene carbonates and ethynyl benzoxazinanones are enabled by NHC/cooper cooperative catalysis, leading to a big library of spirooxindole derivatives in high structural diversity and enantioselectivity (up to 99 % ee). Both reactions represent a nicely synergistic integration of NHC and copper catalysis, in which both catalysts activate the substrates and the chiral NHC perfectly controls the stereochemistry.
资助项目	NSFC[21831007] ; NSFC[21702199] ; Chinese Academy of Science[XDB20000000] ; Anhui Provincial Natural Science Foundation[1808085QB30]
WOS关键词	ISATIN-DERIVED ENALS ; ENANTIOSELECTIVE SYNTHESIS ; SYNERGISTIC CATALYSIS ; DUAL CATALYSIS ; 3+3 ANNULATION ; NHC CATALYSIS ; ACCESS ; ORGANOCATALYSIS ; ALLYLATION ; SCAFFOLDS
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000478399800001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289148]
专题	中国科学院上海药物研究所
通讯作者	Song, Jin; Gong, Liu-Zhu
作者单位	1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China 2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Mol Synth, Hefei 230026, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zi-Jing,Zhang, Ling,Geng, Rui-Long,et al. N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019:6.
APA	Zhang, Zi-Jing,Zhang, Ling,Geng, Rui-Long,Song, Jin,Chen, Xiao-Hua,&Gong, Liu-Zhu.(2019).N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6.
MLA	Zhang, Zi-Jing,et al."N-Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019):6.