Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1

doi:10.16476/j.pibb.2019.0011

	Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1
	Liu Ji-Hao 1,4; Tang Shu-Zhi 1,4; Hu Li-Hong 3; Huang Ming-Dong 2; Chen Zhuo 1,4
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2019-07-01
卷号	46 期号:7 页码:663-672
关键词	tumor therapy plasminogen activator inhibitor-1 tumor microenvironment
ISSN号	1000-3282
DOI	10.16476/j.pibb.2019.0011
通讯作者	Huang Ming-Dong(mhuang@fjirsm.ac.cn) ; Chen Zhuo(zchen@fjirsm.ac.cn)
英文摘要	Cancer is a serious disease that endangers human health. Solid tumors are surrounded by extracellular matrix, infiltrated immune cells, and the secretum of surrounding mesenchymal cells. The tumor microenvironment plays a key role in tumorigenesis, tumor growth, and resistance to antineoplastic therapy. Plasminogen activator inhibitor-1 (PAI-1) is an important regulatory factor in tumor microenvironment. PAI-1 not only functions as a key constitution with tissue-type plasminogen activators (tPA) in regulating fibrinolytic activity, but also participates in invasion, infiltration and migration of tumor. In this paper, the structure and function of PAI-1 and its significance in tumor microenvironment in recent years are reviewed. It is considered that PAI-1 may be an important target for anti-cancer therapy. At the same time, the latest research results of PAI-1 inhibitors in the field of anticancer were analyzed, and the potential application value of PAI-1 inhibitors was demonstrated.
资助项目	National Key R&D Program of China[2017YFE0103200] ; National Natural Science Foudation of China[31370737] ; National Natural Science Foudation of China[81572944] ; CAS/SAFEA International Partnership Program for Creative Research Teams ; High -Level Entrepreneurship and Innovation Talents Projects in Fujian Province[[2018]8-1]
WOS关键词	PAI-1 INHIBITOR ; ENDOTHELIAL-CELLS ; BINDING-SITE ; CANCER ; ANTAGONIST ; EXPRESSION ; MECHANISM ; TYPE-1 ; GENE ; IDENTIFICATION
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS记录号	WOS:000477784600003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289141]
专题	中国科学院上海药物研究所
通讯作者	Huang Ming-Dong; Chen Zhuo
作者单位	1.Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China 2.Fuzhou Univ, Coll Chem, Fuzhou 350116, Fujian, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu Ji-Hao,Tang Shu-Zhi,Hu Li-Hong,et al. Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2019,46(7):663-672.
APA	Liu Ji-Hao,Tang Shu-Zhi,Hu Li-Hong,Huang Ming-Dong,&Chen Zhuo.(2019).Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,46(7),663-672.
MLA	Liu Ji-Hao,et al."Research Progress in Tumor Therapy Targeting Plasminogen Activator Inhibitor-1".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 46.7(2019):663-672.