Isatisindigoticanine A, a novel indole alkaloid with an unpresented carbon skeleton from the roots of Isatis tinctoria

doi:10.1080/14786419.2019.1644632

	Isatisindigoticanine A, a novel indole alkaloid with an unpresented carbon skeleton from the roots of Isatis tinctoria
	Zhang, Dongdong 1; Shi, Yanhong 2; Shi, Songshan 3; Wu, Ximin 1; Zhang, Liudiang 1; Chen, Kaixian 1,4; Li, Yiming 1; Wang, Rui 1
刊名	NATURAL PRODUCT RESEARCH
	2019-07-19
页码	7
关键词	Anti-inflammatory activity indole alkaloid Isatis tinctoria isatisindigoticanine A
ISSN号	1478-6419
DOI	10.1080/14786419.2019.1644632
通讯作者	Li, Yiming(ymlius@163.com) ; Wang, Rui(wr@shutcm.edu.cn)
英文摘要	Isatisindigoticanine A (1), a new indole alkaloid with an unusual carbon skeleton of a benzofuran-3-one unit connected with a 1H-indole-3-yl unit and a 4-(1,2-dihydroxyethyl)-6-oxa-3-azabicyclo[3.1.0]hexan-2-one unit via a C-3C-8'' bond and a C-4'C-8'' bond, was obtained from the roots of Isatis tinctoria. Its structure was determined by physicochemical properties and spectroscopic methods including 1 D, 2 D NMR, IR, HRESIMS data. The absolutely configurations were deduced by comparison of its experimental CD and calculated ECD spectra. Nitric oxide (NO) inhibitory activities of isatisindigoticanine A was also evaluated in the LPS-stimulated RAW 264.7 cells, however, no inhibitory effect was presented.
资助项目	National Natural Science Foundation of China[81573571] ; National Natural Science Foundation of China[81673570] ; Excellent Academic Leaders Program of Shanghai[16XD1403500] ; Shanghai Scientific and Technological Innovation Program[18401931100] ; program of High level University Innovation Team ; program of Shanghai E-Research Institute of Bioactive Constituents in Traditional Chinese Medicine
WOS关键词	GLYCOSIDES ; INDIGOTICA
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000477210500001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289070]
专题	中国科学院上海药物研究所
通讯作者	Li, Yiming; Wang, Rui
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China 2.Univ Tradit Chinese Med, Inst TCM Int Standardizat Shanghai, Shanghai, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Dongdong,Shi, Yanhong,Shi, Songshan,et al. Isatisindigoticanine A, a novel indole alkaloid with an unpresented carbon skeleton from the roots of Isatis tinctoria[J]. NATURAL PRODUCT RESEARCH,2019:7.
APA	Zhang, Dongdong.,Shi, Yanhong.,Shi, Songshan.,Wu, Ximin.,Zhang, Liudiang.,...&Wang, Rui.(2019).Isatisindigoticanine A, a novel indole alkaloid with an unpresented carbon skeleton from the roots of Isatis tinctoria.NATURAL PRODUCT RESEARCH,7.
MLA	Zhang, Dongdong,et al."Isatisindigoticanine A, a novel indole alkaloid with an unpresented carbon skeleton from the roots of Isatis tinctoria".NATURAL PRODUCT RESEARCH (2019):7.