High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care

doi:10.1016/j.apsb.2019.06.003

	High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care
	Li, Jian 1,2; Olaleye, Olajide E.1; Yu, Xuan 1,2; Jia, Weiwei 1; Yang, Junling 1; Lu, Chuang 3; Liu, Songqiao 4; Yu, Jingjing 5; Duan, Xiaona 1; Wang, Yaya 1
刊名	ACTA PHARMACEUTICA SINICA B
	2019-09-01
卷号	9 期号:5 页码:1035-1049
关键词	XueBiJing Antibiotic Combination drug therapy Sepsis Pharmacokinetic compatibility Herb-drug interaction
ISSN号	2211-3835
DOI	10.1016/j.apsb.2019.06.003
通讯作者	Cheng, Chen(chengchen@simm.ac.cn) ; Li, Chuan(chli@simm.ac.cn)
英文摘要	Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding XueBiJing, a five-herb medicine, to antibiotic-based sepsis care. Although adding XueBiJing further reduced 28-day mortality via modulating the host response, pharmacokinetic herb-drug interaction is a widely recognized issue that needs to be studied. Building on our earlier systematic chemical and human pharmacokinetic investigations of XueBiJing, we evaluated the degree of pharmacokinetic compatibility for XueBiJing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both XueBiJing. antibiotic and antibiotic. XueBiJing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study XueBiJing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no XueBiJing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could, due to their inhibition of uridine 5'-diphosphoglucuronosyltransferase 2B15, organic anion transporters 1/2 and/or organic anion-transporting polypeptide 1B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions (resulting in increased exposure) are likely desirable due to these XueBiJing compounds' low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from XueBiJing. Collectively, XueBiJing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
资助项目	National Science & Technology Major Project of China Key New Drug Creation and Manufacturing Program[2017ZX09301012006] ; National Basic Research Program of China[2012CB518403] ; National Natural Science Foundation of China[81503345] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050306]
WOS关键词	DRUG-DRUG INTERACTIONS ; IN-VITRO ; MOLECULAR-MECHANISMS ; METABOLIZING-ENZYMES ; SYSTEMIC EXPOSURE ; INJECTION ; DISPOSITION ; TANSHINOL ; UNIT ; IDENTIFICATION
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号	WOS:000487282700013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288534]
专题	中国科学院上海药物研究所
通讯作者	Cheng, Chen; Li, Chuan
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Sanofi, Dept DMPK, Waltham, MA 02451 USA 4.Southeast Univ, Zhongda Hosp, Sch Med, Dept Crit Care Med, Nanjing 210009, Jiangsu, Peoples R China 5.Univ Washington, Sch Pharm, Seattle, WA 98105 USA 6.Tianjin Chasesun Pharmaceut Co Ltd, Tianjin 301700, Peoples R China
推荐引用方式 GB/T 7714	Li, Jian,Olaleye, Olajide E.,Yu, Xuan,et al. High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care[J]. ACTA PHARMACEUTICA SINICA B,2019,9(5):1035-1049.
APA	Li, Jian.,Olaleye, Olajide E..,Yu, Xuan.,Jia, Weiwei.,Yang, Junling.,...&Li, Chuan.(2019).High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care.ACTA PHARMACEUTICA SINICA B,9(5),1035-1049.
MLA	Li, Jian,et al."High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care".ACTA PHARMACEUTICA SINICA B 9.5(2019):1035-1049.