mhcn1通道孔隙多肽溶液构象的核磁共振研究

	mhcn1通道孔隙多肽溶液构象的核磁共振研究
	眭涛 1; 俞汉钢 2; 胡红雨 3; 施燕红 1; 宋国强 1
刊名	生物化学与生物物理学报
	2003
卷号	35 期号:1 页码:59
关键词	POTASSIUM mHCN1 pore peptide NMR solution structure
ISSN号	0582-9879
英文摘要	Spin systems for amino acid residues in mHCN1 pore region peptide have been identified through analysis of 2D NMR spectra. The sequence-specific assignment of spin systems was obtained by NOEs correlation in WET-NOESY spectra, and the complete assignment of proton resonances for backbone and side chain has been achieved. CNS software was used to calculate the structure of mHCN1 19 aa peptide. The results show that an alpha-helix from residue 10 to residue 13 is formed within the pore region. The results of NMR study on mHCN1 pore peptide provide the basis for further understanding the mechanism of ion selectivity of channels.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/287808]
专题	中国科学院上海药物研究所
作者单位	1.中国科学院上海药物研究所 2.纽约科技学院 3.中国科学院上海生命科学研究院
推荐引用方式 GB/T 7714	眭涛,俞汉钢,胡红雨,等. mhcn1通道孔隙多肽溶液构象的核磁共振研究[J]. 生物化学与生物物理学报,2003,35(1):59.
APA	眭涛,俞汉钢,胡红雨,施燕红,&宋国强.(2003).mhcn1通道孔隙多肽溶液构象的核磁共振研究.生物化学与生物物理学报,35(1),59.
MLA	眭涛,et al."mhcn1通道孔隙多肽溶液构象的核磁共振研究".生物化学与生物物理学报 35.1(2003):59.