ir780loadedpolymericmicellesenhancetheefficacyofphotothermaltherapyintreatingbreastcancerlymphaticmetastasisinmice

doi:10.1038/aps.2017.109

	ir780loadedpolymericmicellesenhancetheefficacyofphotothermaltherapyintreatingbreastcancerlymphaticmetastasisinmice
	He Bin 1; Hu Haiyan 1; Tan Tao 2; Wang Hong 1; Sun Kaoxiang 1; Li Yaping 2; Zhang Zhiwen 2
刊名	actapharmacologicasinica
	2018
卷号	39 期号:1 页码:132
关键词	cancer metastasis lymphatic metastasis IR-780 polymeric micelles photothermal therapy
ISSN号	1671-4083
DOI	10.1038/aps.2017.109
英文摘要	Cancer metastasis is responsible for over 90% of breast cancer-related deaths,and inhibiting lymph node metastasis is an option to treat metastatic disease. Herein, we report the use of IR-780-loaded polymeric micelles (IPMs) for effective photothermal therapy (PTT) of breast cancer lymphatic metastasis. The IPMs were nanometer-sized micelles with a mean diameter of 25.6 nm and had good stability in simulated physiological solutions. Under 808-nm laser irradiation, IPMs exhibited high heat-generating capability in both in vitro and in vivo experiments. After intravenous injection, IPMs specifically accumulated in the tumor and metastatic lymph nodes and penetrated into these tissues. Moreover, a single IPMs treatment plus laser irradiation significantly inhibited primary tumor growth and suppressed lymphatic metastasis by 88.2%. Therefore, IPMs are an encouraging platform for PIT applications in treatment of metastatic breast cancer.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/287068]
专题	中国科学院上海药物研究所
作者单位	1.烟台大学 2.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	He Bin,Hu Haiyan,Tan Tao,et al. ir780loadedpolymericmicellesenhancetheefficacyofphotothermaltherapyintreatingbreastcancerlymphaticmetastasisinmice[J]. actapharmacologicasinica,2018,39(1):132.
APA	He Bin.,Hu Haiyan.,Tan Tao.,Wang Hong.,Sun Kaoxiang.,...&Zhang Zhiwen.(2018).ir780loadedpolymericmicellesenhancetheefficacyofphotothermaltherapyintreatingbreastcancerlymphaticmetastasisinmice.actapharmacologicasinica,39(1),132.
MLA	He Bin,et al."ir780loadedpolymericmicellesenhancetheefficacyofphotothermaltherapyintreatingbreastcancerlymphaticmetastasisinmice".actapharmacologicasinica 39.1(2018):132.