threenewalkaloidsisolatedfromthestemtuberofpinelliapedatisecta

	threenewalkaloidsisolatedfromthestemtuberofpinelliapedatisecta
	Du Jing 2; Ding Jie 2; Mu Zhenqiang 2; Guan Shuhong 1; Cheng Chunru 2; Liu Xuan 3; Guo Dean 1
刊名	chinesejournalofnaturalmedicines
	2018
卷号	016 期号:002 页码:139
关键词	孤立茎碱化学成分光谱数据物理化学混合物醋酸盐
ISSN号	2095-6975
英文摘要	The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Three new alkaloids（compounds 1, 2, and 3） were obtained and identified as 9-（（5-methoxypyridin-2-yl）methyl）-9 H-purin-6-amine（1）, 4-（2-（2, 5-dioxopyrrolidin-1-yl）ethyl）phenyl acetate（2）, and N-（9-（（5-methoxypyridin-2-yl）methyl）-9 H-purin-6-yl）acetamide（3）. These compounds were evaluated for their cytotoxicity against human cervical cancer He La cells. Compounds 1 and 3 significantly inhibited the proliferation of He La cells with IC_（50） values being 3.02 ± 0.54 and 7.16 ± 0.62 μmol·L~（-1）, respectively.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/285883]
专题	中国科学院上海药物研究所
作者单位	1.中国科学院上海药物研究所 2.四川大学 3.上海中医药大学
推荐引用方式 GB/T 7714	Du Jing,Ding Jie,Mu Zhenqiang,et al. threenewalkaloidsisolatedfromthestemtuberofpinelliapedatisecta[J]. chinesejournalofnaturalmedicines,2018,016(002):139.
APA	Du Jing.,Ding Jie.,Mu Zhenqiang.,Guan Shuhong.,Cheng Chunru.,...&Guo Dean.(2018).threenewalkaloidsisolatedfromthestemtuberofpinelliapedatisecta.chinesejournalofnaturalmedicines,016(002),139.
MLA	Du Jing,et al."threenewalkaloidsisolatedfromthestemtuberofpinelliapedatisecta".chinesejournalofnaturalmedicines 016.002(2018):139.