tatfunctionalizedagfe3o4nanocompositesastissuepenetratingvehiclesfortumormagnetictargetinganddrugdelivery

	tatfunctionalizedagfe3o4nanocompositesastissuepenetratingvehiclesfortumormagnetictargetinganddrugdelivery
	Liu Ergang 1; Zhang Meng 2; Cui Hui 3; Gong Junbo 1; Huang Yongzhuo 2; Wang Jianxin 4; Cui Yanna 2; Dong Weibing 1; Sun Lu 3; He Huining 3
刊名	actapharmaceuticasinicab
	2018
卷号	000 期号:006 页码:956
关键词	Cell penetrating peptide Tat Silver nanoparticles Magnetic targeting Fe3O4 Hydrazone bond
ISSN号	2211-3835
英文摘要	In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide（Tat）, producing Tat-modified Ag-Fe3O4 nanocomposites（Tat-FeAgNPs）. To load drugs, an –SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin（Dox） in a pH-sensitive pattern. The delivery efficiency of this system was assessed in vitro using MCF-7 cells, and in vivo using null BalB/c mice bearing MCF-7 xenograft tumors. Our results demonstrated that both Tat and externally applied magnetic field could promote cellular uptake and consequently the cytotoxicity of doxorubicin-loaded nanoparticles,with the IC50 of Tat-FeAgNP-Dox to be 0.63 mmol/L. The in vivo delivery efficiency of Tat-FeAgNP carrying Cy5 to the mouse tumor was analyzed using the in vivo optical imaging tests, in which TatFeAgNP-Cy5 yielded the most efficient accumulation in the tumor（6.772.4% ID of Tat-FeAgNPs）.Anti-tumor assessment also demonstrated that Tat-FeAgNP-Dox displayed the most significant tumor-inhibiting effects and reduced the specific growth rate of tumor by 29.6%（P ? 0.009）, which could be attributed to its superior performance in tumor drug delivery in comparison with the control nanovehicles.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/285776]
专题	中国科学院上海药物研究所
作者单位	1.School of Chemical Engineering and Technology,Tianjin University 2.中国科学院上海药物研究所 3.School of Pharmacy,Tianjin Medical University 4.Department of Pharmaceutics,School of Pharmacy,Fudan University
推荐引用方式 GB/T 7714	Liu Ergang,Zhang Meng,Cui Hui,et al. tatfunctionalizedagfe3o4nanocompositesastissuepenetratingvehiclesfortumormagnetictargetinganddrugdelivery[J]. actapharmaceuticasinicab,2018,000(006):956.
APA	Liu Ergang.,Zhang Meng.,Cui Hui.,Gong Junbo.,Huang Yongzhuo.,...&Yang Victor C.(2018).tatfunctionalizedagfe3o4nanocompositesastissuepenetratingvehiclesfortumormagnetictargetinganddrugdelivery.actapharmaceuticasinicab,000(006),956.
MLA	Liu Ergang,et al."tatfunctionalizedagfe3o4nanocompositesastissuepenetratingvehiclesfortumormagnetictargetinganddrugdelivery".actapharmaceuticasinicab 000.006(2018):956.