tumormicroenvironmentresponsivedocetaxelloadedmicellecombatsmetastaticbreastcancer

	tumormicroenvironmentresponsivedocetaxelloadedmicellecombatsmetastaticbreastcancer
	Tianqun Lang 1; Xinyue Dong 1; Zhong Zheng 1; Yiran Liu 1; Guanru Wang 1; Qi Yin 1; Yaping Li 1
刊名	科学通报英文版
	2019
卷号	000 期号:002 页码:91
关键词	Breast cancer Dual-sensitive micelle Metastasis Tumor-targeting
ISSN号	2095-9273
英文摘要	Efficient tumor-targeting drug delivery systems are urgently needed for treating metastatic breast cancer.In this work, a docetaxel(DTX)-loaded micelle(pDM) as the tumor-microenvironment-responsive delivery platform is developed. The micelle is composed of a pH-sensitive amphiphilic copolymer,poly((1,4-butanediol)-diacrylate-b-N,N-diisopropylethylenediamine)-polyethyleneimine(BD-PEI), and a matrix metalloproteinase(MMP)-responsive polymer, poly((1,4-butanediol)-diacrylate-b-N,N-diisopropy lethylenediamine)-peptide-polyethylene glycol(PEG)(BD-peptide-PEG). The PEG block of BD-peptidePEG will be split by MMPs at the tumor microenvironment, which leads to the change of the surface charge and particle size of the micelle to more positive and smaller one. Owing to this transformation and enhanced permeability and retention(EPR) effect, pDM delivers more DTX into tumor tissues and is internalized more efficiently by tumor cells than the non-MMP-sensitive micelles in the 4 T1 tumorbearing mice model. In addition, DTX is released in acidic endo/lysosomes due to the dissociation of the micelle, triggered by the protonation of the hydrophobic block of BD-PEI. As a result, the DTX-loaded micelle inhibits primary tumor growth and pulmonary metastasis effectively. Thus, this pH/MMP-dual-sensitive drug delivery system, which simultaneously attains three keypoints: prolonged circulation time, directional and efficient uptake into tumor cells, and speedy intracellular drug release, is a promising strategy for metastatic breast cancer therapy.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/284575]
专题	中国科学院上海药物研究所
作者单位	1.State Key Laboratory of Drug Research&Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences 2.中国科学院 3.Nano Science and Technology Institute,University of Science and Technology of China 4.College of Life Sciences,Jilin University 5.School of Pharmacy,Yantai University
推荐引用方式 GB/T 7714	Tianqun Lang,Xinyue Dong,Zhong Zheng,et al. tumormicroenvironmentresponsivedocetaxelloadedmicellecombatsmetastaticbreastcancer[J]. 科学通报英文版,2019,000(002):91.
APA	Tianqun Lang.,Xinyue Dong.,Zhong Zheng.,Yiran Liu.,Guanru Wang.,...&Yaping Li.(2019).tumormicroenvironmentresponsivedocetaxelloadedmicellecombatsmetastaticbreastcancer.科学通报英文版,000(002),91.
MLA	Tianqun Lang,et al."tumormicroenvironmentresponsivedocetaxelloadedmicellecombatsmetastaticbreastcancer".科学通报英文版 000.002(2019):91.