wss25asulfatedpolysaccharideinhibitsranklinducedmouseosteoclastformationbyblockingsmadid1signaling

doi:10.1038/aps.2015.65

	wss25asulfatedpolysaccharideinhibitsranklinducedmouseosteoclastformationbyblockingsmadid1signaling
	Chen Cheng 1; Qin Yi 1; Fang Jianping 1; Ni Xinyan 1; Yao Jian 1; Wang Haiying 2; Ding Kan 1
刊名	actapharmacologicasinica
	2015
卷号	36 期号:9 页码:1053
关键词	KAPPA-B LIGAND BONE-FORMATION RECEPTOR ACTIVATOR CATHEPSIN-K T-CELLS DIFFERENTIATION RESORPTION OSTEOPOROSIS PROTEINS MICE WSS25 polysaccharides osteoclast RANKL BMP-2 Smad1/5/8 Id1 ovariectomized mice osteoporosis
ISSN号	1671-4083
DOI	10.1038/aps.2015.65
英文摘要	Aim: WSS25 is a sulfated polysaccharide extracted from the rhizome of Gastrodia elata BI, which has been found to bind to bone morphogenetic protein 2 (BMP-2) in hepatocellular cancer cells. Since BMP-2 may regulate both osteoclasts and osteoblasts, here we investigated the effects of WSS25 on osteoclastogenesis in vitro and bone loss in ovariectomized mice.
资助项目	[National Natural Science Foundation of China (NSFC)] ; [National Science Fund for Distinguished Young Scholars] ; [New Drug Creation and Manufacturing Program]
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/283241]
专题	中国科学院上海药物研究所
作者单位	1.中国科学院上海药物研究所 2.上海中医药大学
推荐引用方式 GB/T 7714	Chen Cheng,Qin Yi,Fang Jianping,et al. wss25asulfatedpolysaccharideinhibitsranklinducedmouseosteoclastformationbyblockingsmadid1signaling[J]. actapharmacologicasinica,2015,36(9):1053.
APA	Chen Cheng.,Qin Yi.,Fang Jianping.,Ni Xinyan.,Yao Jian.,...&Ding Kan.(2015).wss25asulfatedpolysaccharideinhibitsranklinducedmouseosteoclastformationbyblockingsmadid1signaling.actapharmacologicasinica,36(9),1053.
MLA	Chen Cheng,et al."wss25asulfatedpolysaccharideinhibitsranklinducedmouseosteoclastformationbyblockingsmadid1signaling".actapharmacologicasinica 36.9(2015):1053.