Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor

doi:10.3762/bjoc.15.230

	Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor
	Chai, Xianzhi 2,3; Han, Hai-Hao 1,2,3; Zang, Yi 1; Li, Jia 1; He, Xiao-Peng 2,3; Zhang, Junji 2,3; Tian, He 2,3
刊名	BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
	2019-10-07
卷号	15 页码:2380-2389
关键词	intracellular GSH molecular switches photochromic glycosheet photoswitchable imaging 2D MnO2 nanosheets
ISSN号	1860-5397
DOI	10.3762/bjoc.15.230
通讯作者	Zang, Yi(yzang@simm.ac.cn) ; Zhang, Junji(zhangjunji@ecust.edu.cn)
英文摘要	The development of photochromic fluorescence sensors with dynamic and multiple-signaling is beneficial to the improvement of biosensing/imaging precision. However, elaborate designs with complicated molecular structures are always required to integrate these functions into one molecule. By taking advantages of both redox-active/high loading features of two-dimensional (2D) manganese dioxide (MnO2) and dynamic fluorescence photoswitching of photochromic sensors, we here design a hybrid photochromic MnO2 glycosheet (Glyco-DTE@MnO2) to achieve the photoswitchable imaging of intracellular glutathione (GSH). The photochromic glycosheet manifests significantly turn-on fluorescence and dynamic ON/OFF fluorescence signals in response to GSH, which makes it favorable for intracellular GSH double-check in targeted human hepatoma cell line (HepG2) through the recognition between beta-D-galactoside and asialoglycoprotein receptor (ASGPr) on cell membranes. The dynamic fluorescence signals and excellent selectivity for detection and imaging of GSH ensure the precise determination of cell states, promoting its potential applications in future disease diagnosis and therapy.
资助项目	NSFC[21878086] ; NSFC[21420102004] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; international cooperation program of Shanghai Science and Technology Committee[17520750100] ; Shanghai Rising-Star Program[19QA1402500]
WOS关键词	FLUORESCENT SENSOR ; IN-VIVO ; MNO2 NANOSHEET ; PROBE ; DIARYLETHENES ; CHEMOTHERAPY ; RECEPTORS ; CELLS ; GSH
WOS研究方向	Chemistry
语种	英语
出版者	BEILSTEIN-INSTITUT
WOS记录号	WOS:000489069100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282625]
专题	中国科学院上海药物研究所
通讯作者	Zang, Yi; Zhang, Junji
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China 2.East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China
推荐引用方式 GB/T 7714	Chai, Xianzhi,Han, Hai-Hao,Zang, Yi,et al. Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2019,15:2380-2389.
APA	Chai, Xianzhi.,Han, Hai-Hao.,Zang, Yi.,Li, Jia.,He, Xiao-Peng.,...&Tian, He.(2019).Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,15,2380-2389.
MLA	Chai, Xianzhi,et al."Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 15(2019):2380-2389.