A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones

doi:10.1055/s-0039-1690248

	A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones
	Liu, Fangran 1,2; Zhang, Xiaofei 1; Qian, Qun 2; Yang, Chunhao 1
刊名	SYNTHESIS-STUTTGART
	2020-01-17
卷号	52 期号:2 页码:273-280
关键词	fluoropyrimidine alpha-CF3 aryl ketone metal-free mild conditions
ISSN号	0039-7881
DOI	10.1055/s-0039-1690248
通讯作者	Qian, Qun(qianqun@shu.edu.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要	Herein, a concise and efficient protocol to synthesize a series of 2,6-disubstituted 4-fluoropyrimidines as universal and useful building blocks in medicinal chemistry is reported. From readily accessible alpha-CF3 aryl ketones and different amidine hydrochlorides, this method provides a very practical approach to this kind of compounds under mild conditions with good to excellent yields.
资助项目	National Natural Science Foundation of China[81872722] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Shanghai Sailing Program[17YF1423400] ; SKLDR/Shanghai Institute of Materia Medica (SIMM)[SIMM1601ZZ-03]
WOS关键词	PYRIMIDINE ; INHIBITORS ; FLUORINE ; DESIGN ; CHEMISTRY ; DISCOVERY
WOS研究方向	Chemistry
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000502820600011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282219]
专题	中国科学院上海药物研究所
通讯作者	Qian, Qun; Yang, Chunhao
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ, Dept Chem, 99 Shang Da Rd, Shanghai 200444, Peoples R China
推荐引用方式 GB/T 7714	Liu, Fangran,Zhang, Xiaofei,Qian, Qun,et al. A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones[J]. SYNTHESIS-STUTTGART,2020,52(2):273-280.
APA	Liu, Fangran,Zhang, Xiaofei,Qian, Qun,&Yang, Chunhao.(2020).A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones.SYNTHESIS-STUTTGART,52(2),273-280.
MLA	Liu, Fangran,et al."A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoropyrimidines from alpha-CF3 Aryl Ketones".SYNTHESIS-STUTTGART 52.2(2020):273-280.