Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor

doi:10.1002/smll.201904397

	Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor
	Lai, Yi 2; Xu, Zhiai 2; Hu, Xianli 2; Lei, Li 2; Li, Lingling 2; Dong, Liang 2; Yu, Haijun 1,3; Zhang, Wen 2
刊名	SMALL
	2019-10-22
页码	13
关键词	biomineralization cancer metastasis combination therapy Fenton reaction peptide nanotubes
ISSN号	1613-6810
DOI	10.1002/smll.201904397
通讯作者	Xu, Zhiai(zaxu@chem.ecnu.edu.cn) ; Zhang, Wen(wzhang@chem.ecnu.edu.cn)
英文摘要	1D peptide nanostructures (i.e., peptide nanotubes, PNTs) exhibit tunable chemo-physical properties and functions such as improved tissue adhesion, increased cellular uptake, and elongated blood circulation. In this study, the application of PNTs as a desirable 1D template for biomineralization of Cu2-xS nanoparticles (Cu2-xS NPs, x = 1-2) is reported. Monodisperse Cu2-xS NPs are uniformly coated on the peptide nanotubes owing to the specific high binding affinity of Cu ions to the imidazole groups exposed on the surface of nanotubes. The Cu2-xS NP-coated PNTs are further covalently grafted with an oxaliplatin prodrug (Pt-CuS-PNTs) to construct a versatile nanoplatform for combination cancer therapy. Upon 808 nm laser illumination, the nanoplatform induces significant hyperthermia effect and elicits reactive oxygen species generation through electron transfer and Fenton-like reaction. It is demonstrated that the versatile nanoplatform dramatically inhibits tumor growth and lung metastasis of melanoma in a B16-F10 melanoma tumor-bearing mouse model by combined photo- and chemotherapy. This study highlights the ability of PNTs for biomineralization of metal ions and the promising potential of such nanoplatforms for cancer treatment.
资助项目	National Natural Science Foundation of China[21775046] ; National Natural Science Foundation of China[21675055] ; National Natural Science Foundation of China[21635003] ; Fundamental Research Funds for the Central Universities
WOS关键词	PHOTODYNAMIC THERAPY ; PHOTOTHERMAL THERAPY ; BIOMIMETIC SYNTHESIS ; BREAST-CANCER ; MINERALIZATION ; NANOCRYSTALS ; OXYGEN ; DELIVERY ; CELLS ; NANOCOMPOSITES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000494117200001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281858]
专题	中国科学院上海药物研究所
通讯作者	Xu, Zhiai; Zhang, Wen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Lai, Yi,Xu, Zhiai,Hu, Xianli,et al. Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor[J]. SMALL,2019:13.
APA	Lai, Yi.,Xu, Zhiai.,Hu, Xianli.,Lei, Li.,Li, Lingling.,...&Zhang, Wen.(2019).Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor.SMALL,13.
MLA	Lai, Yi,et al."Peptide Nanotube-Templated Biomineralization of Cu2-xS Nanoparticles for Combination Treatment of Metastatic Tumor".SMALL (2019):13.