Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material

doi:10.1039/c9cc06399d

	Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material
	Dou, Wei-Tao 3; Liu, Li-Fang 3,4; Gao, Jie 3,4; Zang, Yi 4; Chen, Guo-Rong 3; Field, Robert A.1; James, Tony D.2; Li, Jia 4; He, Xiao-Peng 3
刊名	CHEMICAL COMMUNICATIONS
	2019-11-14
卷号	55 期号:88 页码:13235-13238
ISSN号	1359-7345
DOI	10.1039/c9cc06399d
通讯作者	Zang, Yi(yzang@simm.ac.cn) ; Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn)
英文摘要	Protein C receptor (PROCR) is a recently discovered transmembrane biomarker for several tissue stem cells and is highly expressed in triple-negative breast cancer (TNBC) patient-derived xenografts. Herein, to enrich the toolbox for the biochemical evaluation of PROCR, we have developed a peptide-functionalized fluorogenic 2D material based on the self-assembly between a fluorescent peptide probe and thin-layer molybdenum disulfide. The material developed was suitable for the sensitive detection of PROCR recombinant protein in buffer solution and the fluorescence imaging of TNBC cells that express high levels of PROCR.
资助项目	Natural Science Foundation of China[21788102] ; Natural Science Foundation of China[91853201] ; Natural Science Foundation of China[21722801] ; Natural Science Foundation of China[21776078] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; Shanghai Science and Technology Committee[19410712600] ; National Postdoctoral Program for Innovative Talents[BX20190115] ; Royal Society
WOS关键词	PROTEIN-C RECEPTOR ; ACTIVATION
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000495086800004
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281766]
专题	中国科学院上海药物研究所
通讯作者	Zang, Yi; Li, Jia; He, Xiao-Peng
作者单位	1.John Innes Ctr, Dept Biol Chem, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England 2.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 3.East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Dou, Wei-Tao,Liu, Li-Fang,Gao, Jie,et al. Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material[J]. CHEMICAL COMMUNICATIONS,2019,55(88):13235-13238.
APA	Dou, Wei-Tao.,Liu, Li-Fang.,Gao, Jie.,Zang, Yi.,Chen, Guo-Rong.,...&He, Xiao-Peng.(2019).Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material.CHEMICAL COMMUNICATIONS,55(88),13235-13238.
MLA	Dou, Wei-Tao,et al."Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material".CHEMICAL COMMUNICATIONS 55.88(2019):13235-13238.