Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice

doi:10.1016/j.ijbiomac.2019.09.177

	Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice
	Zhou, Yue 3; Duan, Yanhong 4; Huang, Shichao 6; Zhou, Xuan 4; Zhou, Lishuang 1; Hu, Tingting 3; Yang, Yongfeng 3; Lu, Jing 3; Ding, Kan 1; Guo, Dean 7
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2020-02-01
卷号	144 页码:1004-1012
关键词	Lycium barbarum polysaccharides Alzheimer's disease Amyloid-beta Synaptic plasticity Neuropathology
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2019.09.177
通讯作者	Ding, Kan(dingkan@simm.ac.cn) ; Guo, Dean(daguo@simm.ac.cn) ; Cao, Xiaohua(xhcao@brain.ecnu.edu.cn) ; Pei, Gang(gpei@sibs.ac.cn)
英文摘要	Alzheimer's disease (AD) is the most common degenerative disease of the central nervous system. It is associated with abnormal accumulation of amyloid-beta (A beta) plaques, impaired neurogenesis, and damaged cognitive functions. We have known for a long time that natural compounds and their derivatives have gained increasing attention in AD drug research due to their multiple effects and inherently enormous chemicals. In this study, we will demonstrate that polysaccharides from L. barbarum (LBP1), a traditional natural compound, can reduce A beta level and improve the cognitive functions in APP/PSI transgenic mouse. LBP1 can enhance neurogenesis as indicated by BrdU/NeuN double labeling. Furthermore, it can restore synaptic dysfunction at hippocampus CA3-CA1 pathway. Additionally, in vitro cell assay indicates that LBP1 may affect A beta processing. In conclusion, our study indicates that LBP1 might be a potential therapeutic agent for the treatment of AD against multiple targets that include synaptic plasticity, A beta pathology and neuropathology. (C) 2019 The Authors. Published by Elsevier B.V.
资助项目	National Key Research and Development Program of China[2018YFA0108003] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16010309] ; Ministry of Science and Technology[2015CB964502] ; MOST China-Israel cooperation[2016YFE0130500]
WOS关键词	SYNAPTIC PLASTICITY ; BETA ; FRUITS ; OLIGOMERS ; L. ; NEUROGENESIS ; TOXICITY ; CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000515200700103
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281563]
专题	中国科学院上海药物研究所
通讯作者	Ding, Kan; Guo, Dean; Cao, Xiaohua; Pei, Gang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Medica, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Chinese Acad Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China 4.East China Normal Univ, Shanghai Key Lab Brain Funct Genom, Sch Life Sci, Key Lab Brain Funct Genom,Minist Educ, Shanghai, Peoples R China 5.Tongji Univ, Shanghai Key Lab Signaling & Dis Res, Sch Life Sci & Technol, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China 6.Tongji Univ, Sch Life Sci & Technol, Collaborat Innovat Ctr Brain Sci, Shanghai 200092, Peoples R China 7.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Medica, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Yue,Duan, Yanhong,Huang, Shichao,et al. Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,144:1004-1012.
APA	Zhou, Yue.,Duan, Yanhong.,Huang, Shichao.,Zhou, Xuan.,Zhou, Lishuang.,...&Pei, Gang.(2020).Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,144,1004-1012.
MLA	Zhou, Yue,et al."Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 144(2020):1004-1012.