Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy

doi:10.1016/j.jconrel.2019.12.028

	Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy
	Wang, Hong 2,3,6; Li, Jie 2,3,6; Wang, Yuqi 2,3; Gong, Xiang 2,3,6; Xu, Xiaoxuan 2,3,6; Wang, Jiaoying 2,3; Li, Yaping 2,3,5; Sha, Xianyi 1; Zhang, Zhiwen 2,3,4
刊名	JOURNAL OF CONTROLLED RELEASE
	2020-03-10
卷号	319 页码:25-45
关键词	Tumor hypoxia Nanoparticles Oxygen Cancer therapy
ISSN号	0168-3659
DOI	10.1016/j.jconrel.2019.12.028
通讯作者	Li, Yaping(ypli@simm.ac.cn) ; Zhang, Zhiwen(zwzhang0125@simm.ac.cn)
英文摘要	Tumor hypoxia is a characteristic hallmark of malignant solid tumors, which remains an essential impediment to many current treatments like chemotherapy, radiotherapy, photodynamic therapy and immunotherapy, thereby leading to poor clinical prognosis after therapy. Rationally, modulating tumor hypoxia can be of great interest to augment the therapeutic efficacy of these treatments. In this review, we focus our discussion on current advances in nanoparticles-mediated tumor reoxygenation strategy for relieving tumor hypoxia to improve the therapeutic efficacy of versatile therapies. These nanoparticles can improve tumor oxygen levels via nanoparticles-mediated oxygen-carrying or oxygen-generating tactics to synergize the effectiveness of many current therapeutic modalities. Based on these considerable summaries and analyses, we propose some feasible perspectives on nanoparticles-based tumor reoxygenations to ameliorate the therapeutic outcomes.
资助项目	Strategic Priority Research Program of CAS[XDA12050307] ; National Natural Science Foundation of China[31771092] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2012223] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005]
WOS关键词	PHOTODYNAMIC THERAPY ; BLOOD SUBSTITUTES ; OXYGEN ; RADIOTHERAPY ; DELIVERY ; MICROENVIRONMENT ; CHEMOTHERAPY ; METASTASIS ; RESISTANCE ; HEMOGLOBIN
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000515538300003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281408]
专题	中国科学院上海药物研究所
通讯作者	Li, Yaping; Zhang, Zhiwen
作者单位	1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Shandong 264000, Peoples R China 5.Yantai Univ, Sch Pharm, Shandong 264000, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hong,Li, Jie,Wang, Yuqi,et al. Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy[J]. JOURNAL OF CONTROLLED RELEASE,2020,319:25-45.
APA	Wang, Hong.,Li, Jie.,Wang, Yuqi.,Gong, Xiang.,Xu, Xiaoxuan.,...&Zhang, Zhiwen.(2020).Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy.JOURNAL OF CONTROLLED RELEASE,319,25-45.
MLA	Wang, Hong,et al."Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy".JOURNAL OF CONTROLLED RELEASE 319(2020):25-45.