Intestinal Transporter-Associated Drug Absorption and Toxicity

doi:10.1007/978-981-13-7647-4_8

	Intestinal Transporter-Associated Drug Absorption and Toxicity
	Xue, Yaru 2,3; Ma, Chenhui 2,3; Hanna, Imad 1; Pan, Guoyu 2,3
刊名	DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY
	2019
卷号	1141 页码:361-405
关键词	Intestinal transporter Drug absorption Bile acid transport BDDCS Drug-induced toxicity
ISSN号	0065-2598
DOI	10.1007/978-981-13-7647-4_8
通讯作者	Hanna, Imad(Imad.hanna@novartis.com) ; Pan, Guoyu(gypan@simm.ac.cn)
英文摘要	Oral drug administration is the most favorable route of drug administration in the clinic. Intestinal transporters have been shown to play a significant role in the rate and extent of drug absorption of some, but not all, drug molecules. Due to the heterogeneous expression of multiple transporters along the intestine, the preferential absorption sites for drugs may vary significantly. In this chapter, we aim to summarize the current research on the expression, localization, function, and regulation of human intestinal transporters implicated in altering the absorption of low to medium molecular weight drug molecules. The role played by bile acid transport proteins (e.g., ASBT and OST-alpha/beta) is included in the discussion. The synergistic action of intestinal drug metabolism and transport is also discussed. Despite the complicated regulatory factors, the biopharmaceutics drug disposition classification system (BDDCS) put forward by Wu and Benet may help us better predict the effect of transporters on drug absorption. The drug-induced toxicity in the intestine, which may result from drug-drug interaction, gut microbiota, and bile salt toxicity, is also discussed.
WOS关键词	CANCER RESISTANCE PROTEIN ; ORGANIC CATION TRANSPORTERS ; BILE-ACID METABOLISM ; NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; MESSENGER-RNA EXPRESSION ; ATP-BINDING CASSETTE ; ALPHA-OST-BETA ; INFLAMMATORY-BOWEL-DISEASE ; P-GLYCOPROTEIN INCREASES ; FARNESOID-X RECEPTOR
WOS研究方向	Cell Biology ; Research & Experimental Medicine ; Pharmacology & Pharmacy
语种	英语
出版者	SPRINGER INTERNATIONAL PUBLISHING AG
WOS记录号	WOS:000514283700009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281367]
专题	中国科学院上海药物研究所
通讯作者	Hanna, Imad; Pan, Guoyu
作者单位	1.Novartis Inst Biomed Res, E Hanover, NJ 07936 USA 2.Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Xue, Yaru,Ma, Chenhui,Hanna, Imad,et al. Intestinal Transporter-Associated Drug Absorption and Toxicity[J]. DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY,2019,1141:361-405.
APA	Xue, Yaru,Ma, Chenhui,Hanna, Imad,&Pan, Guoyu.(2019).Intestinal Transporter-Associated Drug Absorption and Toxicity.DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY,1141,361-405.
MLA	Xue, Yaru,et al."Intestinal Transporter-Associated Drug Absorption and Toxicity".DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY 1141(2019):361-405.