A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer's Disease

doi:10.3390/ijms21051766

	A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer's Disease
	Wu, Wenyong 1,2; Zhang, Zijia 1; Li, Feifei 1,2; Deng, Yanping 1; Lei, Min 1; Long, Huali 1; Hou, Jinjun 1; Wu, Wanying 1
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2020-03-01
卷号	21 期号:5 页码:19
关键词	Uncaria alkaloids network pharmacology hypertension Alzheimer's disease butyrylcholinesterase molecular docking
DOI	10.3390/ijms21051766
通讯作者	Hou, Jinjun(jinjun_hou@simm.ac.cn) ; Wu, Wanying(wanyingwu@simm.ac.cn)
英文摘要	Uncaria alkaloids are the major bioactive chemicals found in the Uncaria genus, which have a long history of clinical application in treating cardiovascular and mental diseases in traditional Chinese medicine (TCM). However, there are gaps in understanding the multiple targets, pathways, and biological activities of Uncaria alkaloids. By constructing the interactions among drug-targets-diseases, network pharmacology provides a systemic methodology and a novel perspective to present the intricate connections among drugs, potential targets, and related pathways. It is a valuable tool for studying TCM drugs with multiple indications, and how these multi-indication drugs are affected by complex interactions in the biological system. To better understand the mechanisms and targets of Uncaria alkaloids, we built an integrated analytical platform based on network pharmacology, including target prediction, protein-protein interaction (PPI) network, topology analysis, gene enrichment analysis, and molecular docking. Using this platform, we revealed the underlying mechanisms of Uncaria alkaloids' anti-hypertensive effects and explored the possible application of Uncaria alkaloids in preventing Alzheimer's disease. These results were further evaluated and refined using biological experiments. Our study provides a novel strategy for understanding the holistic pharmacology of TCM, as well as for exploring the multi-indication properties of TCM beyond its traditional applications.
资助项目	National Natural Science Foundation of China[81673591]
WOS关键词	TRADITIONAL CHINESE MEDICINE ; DRUG TARGET IDENTIFICATION ; BUTYRYLCHOLINESTERASE ACTIVITY ; MOUSE MODEL ; WEB SERVER ; RHYNCHOPHYLLINE ; PHARMACOLOGY ; ARTEMISININ ; IMPAIRMENT ; CYTOSCAPE
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000524908500217
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281108]
专题	中国科学院上海药物研究所
通讯作者	Hou, Jinjun; Wu, Wanying
作者单位	1.Chinese Acad Sci, Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Wenyong,Zhang, Zijia,Li, Feifei,et al. A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer's Disease[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(5):19.
APA	Wu, Wenyong.,Zhang, Zijia.,Li, Feifei.,Deng, Yanping.,Lei, Min.,...&Wu, Wanying.(2020).A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer's Disease.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(5),19.
MLA	Wu, Wenyong,et al."A Network-Based Approach to Explore the Mechanisms of Uncaria Alkaloids in Treating Hypertension and Alleviating Alzheimer's Disease".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.5(2020):19.