Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature

doi:10.1016/j.tetlet.2020.151780

	Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature
	Yi, Xing 1; Cao, Ya-Fang 4; Wang, Xing 2,3; Xu, Hui 2; Ban, Shu-Rong 1; Dai, Hui-Xiong 2,3
刊名	TETRAHEDRON LETTERS
	2020-04-16
卷号	61 期号:16 页码:4
关键词	Fluoroacylation Arylboronic acid Cross coupling Late-stage diversification of drugs
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2020.151780
通讯作者	Xu, Hui(xuhui2018@simm.ac.cn) ; Ban, Shu-Rong(shurongban@sxmu.edu.cn) ; Dai, Hui-Xiong(hxdai@simm.ac.cn)
英文摘要	A palladium-catalyzed fluoroacylation of (hetero)aryl boronic acid with the fluorothioacetates is described at ambient temperature. A variety of aryl, and heteroaryl boronic acids are compatible in the reaction, affording the corresponding fluoroalkyl ketones in moderate to good yields. Further late-stage di-, and trifluoroacylation of drug molecule clofibrate and estrone demonstrated the synthetic practicability of this protocol.2009 Elsevier Ltd. All rights reserved. (C) 2020 Elsevier Ltd. All rights reserved.
资助项目	Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; NSFC[21772211] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Program of Shanghai Academic Research Leader[19XD1424600] ; Primary Research & Developement Plan of Shanxi Province[201903D321110] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006]
WOS关键词	COPPER-MEDIATED TRIFLUOROACETYLATION ; ARYL BORONIC ACIDS ; TRIFLUOROMETHYL KETONES ; ALPHA,ALPHA-DIFLUORO KETONES ; DIFLUOROMETHYL KETONES ; EFFICIENT SYNTHESIS ; INHIBITORS ; OXIDATION ; CARBONYLATION ; BROMIDES
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000527104000011
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281066]
专题	中国科学院上海药物研究所
通讯作者	Xu, Hui; Ban, Shu-Rong; Dai, Hui-Xiong
作者单位	1.Shanxi Med Univ, Sch Pharmaceut Sci, 56 Xinjian South Rd, Taiyuan 030001, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Yi, Xing,Cao, Ya-Fang,Wang, Xing,et al. Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature[J]. TETRAHEDRON LETTERS,2020,61(16):4.
APA	Yi, Xing,Cao, Ya-Fang,Wang, Xing,Xu, Hui,Ban, Shu-Rong,&Dai, Hui-Xiong.(2020).Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature.TETRAHEDRON LETTERS,61(16),4.
MLA	Yi, Xing,et al."Palladium-catalyzed fluoroacylation of (Hetero)arylboronic acid with fluorothioacetates at ambient temperature".TETRAHEDRON LETTERS 61.16(2020):4.