Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis

doi:10.1038/s41419-020-2470-8

	Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis
	Li, Heng 1,3; Feng, Chunlan 3; Fan, Chen 3; Yang, Yang 2; Yang, Xiaoqian 3; Lu, Huimin 1,3; Lu, Qiukai 1,3; Zhu, Fenghua 3; Xiang, Caigui 1,3; Zhang, Zongwang 3
刊名	CELL DEATH & DISEASE
	2020-04-24
卷号	11 期号:4 页码:17
ISSN号	2041-4889
DOI	10.1038/s41419-020-2470-8
通讯作者	Zuo, Jianping(jpzuo@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn)
英文摘要	Ulcerative colitis (UC) is a chronic and etiologically refractory inflammatory gut disorder. Although berberine, an isoquinoline alkaloid, has been revealed to exert protective effects on experimental colitis, the underlying molecular mechanism in chronic intestinal inflammation remains ill-defined. This study was designed to uncover the therapeutic efficacy and immunomodulatory role of berberine in chronic UC. Therapeutic effects of oral administration of berberine were investigated in dextran sodium sulfate (DSS)-induced murine chronic UC and the underlying mechanisms were further identified by si-OSMR transfection in human intestinal stromal cells. Berberine significantly attenuated the experimental symptoms and gut inflammation of chronic UC. Berberine treatment could also maintain the intestinal barrier function and rectify tissue fibrosis. In accordance with infiltrations of antigen-presenting cells (APCs), innate lymphoid cells (ILCs), and activated NK cells in colonic lamina propria, increased expression of OSM and OSMR were observed in the inflamed tissue of chronic UC, which were decreased following berberine treatment. Moreover, berberine inhibited the overactivation of human intestinal stromal cells through OSM-mediated JAK-STAT pathway, which was obviously blocked upon siRNA targeting OSMR. The research provided an infusive mechanism of berberine and illustrated that OSM and OSMR intervention might function as the potential target in chronic UC.
资助项目	Science & Technology Commission of Shanghai Municipality, China[18431907100]
WOS关键词	BOWEL-DISEASE ; INTESTINAL FIBROSIS ; BARRIER FUNCTION ; CLASSIFICATION ; EXPRESSION ; MODELS ; COLON ; MICE
WOS研究方向	Cell Biology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000530255700002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280551]
专题	中国科学院上海药物研究所
通讯作者	Zuo, Jianping; Tang, Wei
作者单位	1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat & Immunopharmacol, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Heng,Feng, Chunlan,Fan, Chen,et al. Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis[J]. CELL DEATH & DISEASE,2020,11(4):17.
APA	Li, Heng.,Feng, Chunlan.,Fan, Chen.,Yang, Yang.,Yang, Xiaoqian.,...&Tang, Wei.(2020).Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis.CELL DEATH & DISEASE,11(4),17.
MLA	Li, Heng,et al."Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis".CELL DEATH & DISEASE 11.4(2020):17.