Palladium-catalyzed meta-C-H bond iodination of arenes with I-2

doi:10.1016/j.cclet.2019.09.057

	Palladium-catalyzed meta-C-H bond iodination of arenes with I-2
	Liu, Min 1,2,3; Li, Ling-Jun 1,2,3; Zhang, Jun 3,4; Xu, Hui 1,2,3; Dai, Hui-Xiong 1,2,3
刊名	CHINESE CHEMICAL LETTERS
	2020-05-01
卷号	31 期号:5 页码:1301-1304
关键词	Palladium catalysis meta-C-H iodination Pyridine-based template Practical ester linkages Molecular I-2
ISSN号	1001-8417
DOI	10.1016/j.cclet.2019.09.057
通讯作者	Xu, Hui(xuhui2018@simm.ac.cn) ; Dai, Hui-Xiong(hxdai@simm.ac.cn)
英文摘要	Palladium-catalyzed highly meta-selective C-H iodination of phenylacetic acid, benzylphosphonate and benzylsulfonate scaffolds with molecular I-2 is developed using a pyridine-type template. The practical ester linkages enable the directing template easily installed and readily removed. The substrate scope is broad, and alkyl, methoxyl, trifluomethyl, and halo substituents are compatible with this reaction. Further transformations of ibuprofen iodide intermediates by Pd-catalyzed C-C and C-heteroatom bond formation illustrate the broad utility of this method. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[21772211] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; State Key Laboratory of Natural and Biomimetic Drugs ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences
WOS关键词	REGIOSELECTIVE HALOGENATION ; COUPLING REACTIONS ; N-OXIDES ; ACTIVATION ; BORYLATION ; FUNCTIONALIZATION ; LIGAND ; ARYL ; BROMINATION ; OLEFINATION
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000531056900054
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280317]
专题	中国科学院上海药物研究所
通讯作者	Xu, Hui; Dai, Hui-Xiong
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 4.Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Peoples R China
推荐引用方式 GB/T 7714	Liu, Min,Li, Ling-Jun,Zhang, Jun,et al. Palladium-catalyzed meta-C-H bond iodination of arenes with I-2[J]. CHINESE CHEMICAL LETTERS,2020,31(5):1301-1304.
APA	Liu, Min,Li, Ling-Jun,Zhang, Jun,Xu, Hui,&Dai, Hui-Xiong.(2020).Palladium-catalyzed meta-C-H bond iodination of arenes with I-2.CHINESE CHEMICAL LETTERS,31(5),1301-1304.
MLA	Liu, Min,et al."Palladium-catalyzed meta-C-H bond iodination of arenes with I-2".CHINESE CHEMICAL LETTERS 31.5(2020):1301-1304.