Nonparametric estimation of distributions and diagnostic accuracy based on group-tested results with differential misclassification

doi:10.1111/biom.13236

CORC > 数学与系统科学研究院 > 中国科学院数学与系统科学研究院 > 系统科学研究所

	Nonparametric estimation of distributions and diagnostic accuracy based on group-tested results with differential misclassification
	Zhang, Wei 1; Liu, Aiyi 2; Li, Qizhai 1; Albert, Paul S.3
刊名	BIOMETRICS
	2020-03-05
页码	10
关键词	coverage probability diagnostic accuracy differential misclassification group testing integrated absolute bias integrated mean squared error rare disease ROC curves
ISSN号	0006-341X
DOI	10.1111/biom.13236
英文摘要	This article concerns the problem of estimating a continuous distribution in a diseased or nondiseased population when only group-based test results on the disease status are available. The problem is challenging in that individual disease statuses are not observed and testing results are often subject to misclassification, with further complication that the misclassification may be differential as the group size and the number of the diseased individuals in the group vary. We propose a method to construct nonparametric estimation of the distribution and obtain its asymptotic properties. The performance of the distribution estimator is evaluated under various design considerations concerning group sizes and classification errors. The method is exemplified with data from the National Health and Nutrition Examination Survey study to estimate the distribution and diagnostic accuracy of C-reactive protein in blood samples in predicting chlamydia incidence.
资助项目	Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ; Beijing Natural Science Foundation[Z180006] ; National Nature Science Foundation of China[11722113] ; Intramural Research Program of theNational Cancer Institute (NCI)
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology ; Mathematics
语种	英语
出版者	WILEY
WOS记录号	WOS:000560958200001
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/52039]
专题	系统科学研究所
通讯作者	Liu, Aiyi
作者单位	1.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, LSC, Beijing, Peoples R China 2.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biostat & Bioinformat Branch, NIH, Bethesda, MD 20892 USA 3.NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
推荐引用方式 GB/T 7714	Zhang, Wei,Liu, Aiyi,Li, Qizhai,et al. Nonparametric estimation of distributions and diagnostic accuracy based on group-tested results with differential misclassification[J]. BIOMETRICS,2020:10.
APA	Zhang, Wei,Liu, Aiyi,Li, Qizhai,&Albert, Paul S..(2020).Nonparametric estimation of distributions and diagnostic accuracy based on group-tested results with differential misclassification.BIOMETRICS,10.
MLA	Zhang, Wei,et al."Nonparametric estimation of distributions and diagnostic accuracy based on group-tested results with differential misclassification".BIOMETRICS (2020):10.