Epidemiology characteristics of the clonal complexes of Mycobacterium tuberculosis Lineage 4 in China

doi:10.1016/j.meegid.2020.104363

	Epidemiology characteristics of the clonal complexes of Mycobacterium tuberculosis Lineage 4 in China
	Ni, Xumin 6; Zhu, Chendi 1,7; Li, Qing 8; Jiang, Hui 1,7; Liu, Jingyi 5; Chen, Zhi 4; He, Li 3; Jia, Junnan 1,7; Zhang, Zongde 1; Ma, Liang 2
刊名	INFECTION GENETICS AND EVOLUTION
	2020-10-01
卷号	84 页码:7
关键词	Mycobacterium tuberculosis Lineage 4 Clonal complexes Geographical distribution Epidemiology characteristics
ISSN号	1567-1348
DOI	10.1016/j.meegid.2020.104363
英文摘要	Mycobacterium tuberculosis (M. tuberculosis) Lineage 4 (L4) is frequently prevailing in Western regions of China, where the tuberculosis incidence rate is high. However, the epidemiology characteristics of M. tuberculosis L4 in China remain poorly understood. Here, the 15-loci Variable number of tandem repeats (VNTR) patterns of 975 L4 isolates from a National Survey of Tuberculosis in China were used to construct a Minimum Spanning Tree (MST), which divided the 975 isolates into 5 major clonal complexes (CC; named CC1 to CC5). We found that the CCs of M. tuberculosis L4 were nationally distributed, geographically restricted, and different in epidemiology characteristics. For example, CC1 was mainly concentrated in East and Central China and significantly related to the farmer occupation and income of an individual (4200 yuan) (p < .05); CC5 was mainly distributed in Southwest China and was associated with ethnic minorities. Notably, using whole genome sequencing (WGS) data of 141 strains that matched our samples, we found that both CC1 and CC5 were mapped to the sublineage L4.5. Nevertheless, due to the difference of geographical distribution, the epidemiology characteristics of these CCs were largely different. We found that income and occupation significantly contributed to the odds of infection by CC1 to CC5. Consequently, our findings revealed the epidemiology characteristics of the CCs of M. tuberculosis L4, and will help in the formulation of more effective intervention measures in line with regional specifications and patient characteristics in China.
资助项目	Fundamental Research Funds for the Central Universities[2020RC001] ; Fundamental Research Funds for the Central Universities[2017YJS197] ; Fundamental Research Funds for the Central Universities[2018JBM320] ; National Science and Technology Major Project of China[2018ZX10302302001004] ; National Natural Science Foundation of China[U1903118] ; National Natural Science Foundation of China[11801027] ; National Key Research and Development Program[2018YFC2000300]
WOS研究方向	Infectious Diseases
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000572874800013
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/52241]
专题	中国科学院数学与系统科学研究院
通讯作者	Ma, Liang; Li, Weimin
作者单位	1.Capital Med Univ, Beijing Chest Hosp, Beijing Key Lab Drug Resistance TB Res, Beijing 101149, Peoples R China 2.Chinese Acad Sci, Inst Zool, Key Lab Zool Systemat & Evolut, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China 4.Capital Normal Univ, Sch Math Sci, Beijing 100048, Peoples R China 5.Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Peoples R China 6.Beijing Jiaotong Univ, Sch Sci, Dept Math, Beijing 100044, Peoples R China 7.Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Natl TB Clin Lab China, Beijing 101149, Peoples R China 8.Capital Med Univ, Resp Med, Miyun Teaching Hosp, Beijing 101500, Peoples R China
推荐引用方式 GB/T 7714	Ni, Xumin,Zhu, Chendi,Li, Qing,et al. Epidemiology characteristics of the clonal complexes of Mycobacterium tuberculosis Lineage 4 in China[J]. INFECTION GENETICS AND EVOLUTION,2020,84:7.
APA	Ni, Xumin.,Zhu, Chendi.,Li, Qing.,Jiang, Hui.,Liu, Jingyi.,...&Li, Weimin.(2020).Epidemiology characteristics of the clonal complexes of Mycobacterium tuberculosis Lineage 4 in China.INFECTION GENETICS AND EVOLUTION,84,7.
MLA	Ni, Xumin,et al."Epidemiology characteristics of the clonal complexes of Mycobacterium tuberculosis Lineage 4 in China".INFECTION GENETICS AND EVOLUTION 84(2020):7.