Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones

CORC > 金属研究所 > 中国科学院金属研究所

	Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones
	Zhao Yue 1; Han Xiao 2; Zhou XiaoXia 1; Li HaiHua 1; You ZhongLu 1
刊名	CHINESE JOURNAL OF INORGANIC CHEMISTRY
	2013
卷号	29 期号:4 页码:867-874
关键词	CRYSTAL-STRUCTURE COORDINATION CHEMISTRY METAL-COMPLEXES IN-VITRO LIGANDS DERIVATIVES CHELATORS AMMONIA SOIL hydrazone oxovanadium(V) complex crystal structure urease inhibitor
ISSN号	1001-4861
其他题名	Synthesis,Structures,and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones
英文摘要	In order to explore new and efficient urease inhibitors, two new oxovanadium (V) complexes, VOL1 (OCH3)(CH3OH) (1) and VOL2(mu-OCH3)(2) (2) (H2L1=N'-(5-chloro-2-hydroxybenzylidene)-3-nitrobenzohydrazide; H2L2=N'-(5-chloro-2-hydroxybenzylidene)-4-chlorobenzohydrazide), have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. Compound 1 is a mononuclear complex, and compound 2 is a bis-methanolato bridged centrosymmetric dinuclear complex. The V atom in each complex adopts an octahedral coordination. Thermal stability and urease inhibitory activities of the complexes were studied. The percent inhibition at the concentration of 100 mu mol . L-1 on Helicobacter pylori urease is 71.4% for 1 and 73.3% for 2. The IC50 values for 1 and 2 are 63.6 and 37.7 mu mol . L-1, respectively. CCDC: 858857, 1; and 858858, 2.
语种	英语
CSCD记录号	CSCD:4833328
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/149825]
专题	金属研究所_中国科学院金属研究所
作者单位	1.辽宁师范大学 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhao Yue,Han Xiao,Zhou XiaoXia,et al. Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2013,29(4):867-874.
APA	Zhao Yue,Han Xiao,Zhou XiaoXia,Li HaiHua,&You ZhongLu.(2013).Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones.CHINESE JOURNAL OF INORGANIC CHEMISTRY,29(4),867-874.
MLA	Zhao Yue,et al."Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(V) Complexes with Hydrazones".CHINESE JOURNAL OF INORGANIC CHEMISTRY 29.4(2013):867-874.