Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives

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	Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives
	Sun ChiYu 1; Li YangSheng 1; Shi AiLong 1; Li YaFei 1; Cao RuiFang 1; Ding HuaiWei 1; Yin QingQing 1; Zhang LiJuan 1; Zheng HuaChuan 2; Song HongRui 1
刊名	CHINESE CHEMICAL LETTERS
	2015
卷号	26 期号:10 页码:1307-1310
关键词	HEDGEHOG SIGNALING PATHWAY BASAL-CELL CARCINOMA INHIBITORS DISCOVERY DESIGN ANTAGONISTS IDENTIFICATION VISMODEGIB CANCER POTENT Aryl cycloaliphatic amine Antiproliferative activity Hedgehog signaling
ISSN号	1001-8417
其他题名	Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives
英文摘要	A series of novel 4-substituted-phenoxy-benzamide derivatives bearing an aryl cycloaliphatic amine moiety were synthesized and evaluated for antiproliferative activity against SW620, HT29 and MGC803 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of target compounds exhibited moderate efficacy in HT29 and MGC803 cell lines. Compound 10c showed promising inhibition of hedgehog (Hh) signaling pathway in an Hh-related assay. In addition, the superposition pattern of 10c showed a good fit for a pharmacophoric model generated by Hh inhibitors and provided a basis for further structural optimization. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
资助项目	[Program for Innovative Research Team of the Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University] ; [Innovation and entrepreneurship training program for college students in Liaoning Province]
语种	英语
CSCD记录号	CSCD:5542180
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/144038]
专题	金属研究所_中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Liaoning Med University, Affiliated Hosp 1, Jinzhou 121001, Peoples R China
推荐引用方式 GB/T 7714	Sun ChiYu,Li YangSheng,Shi AiLong,et al. Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives[J]. CHINESE CHEMICAL LETTERS,2015,26(10):1307-1310.
APA	Sun ChiYu.,Li YangSheng.,Shi AiLong.,Li YaFei.,Cao RuiFang.,...&Song HongRui.(2015).Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives.CHINESE CHEMICAL LETTERS,26(10),1307-1310.
MLA	Sun ChiYu,et al."Synthesis and antiproliferative activity of novel 4-substituted-phenoxy-benzamide derivatives".CHINESE CHEMICAL LETTERS 26.10(2015):1307-1310.