An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics

doi:10.1155/2020/7289208

CORC > 金属研究所 > 中国科学院金属研究所

	An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics
	Zhao, Xue 4; Wan, Peng 3; Wang, Hongyan 4; Zhang, Shuwei 4; Liu, Jingbo 4; Chang, Chunrong 4; Yang, Ke 2; Pan, Yaping 1,4
刊名	BIOMED RESEARCH INTERNATIONAL
	2020-08-28
卷号	2020 页码:9
ISSN号	2314-6133
DOI	10.1155/2020/7289208
通讯作者	Yang, Ke(kyang@imr.ac.cn) ; Pan, Yaping(yppan@cmu.edu.cn)
英文摘要	Periodontal diseases are mainly the results of infections and inflammation of the gum and bone that surround and support the teeth. In this study, the alveolar bone destruction in periodontitis is hypothesized to be treated with novel Mg-Cu alloy grafts due to their antimicrobial and osteopromotive properties. In order to study this new strategy using Mg-Cu alloy grafts as a periodontal bone substitute, thein vitrodegradation and antibacterial performance were examined. The pH variation and Mg2+ and Cu2+ release of Mg-Cu alloy extracts were measured.Porphyromonas gingivalis(P. gingivalis) andAggregatibacter actinomycetemcomitans(A. actinomycetemcomitans), two common bacteria associated with periodontal disease, were cultured in Mg-Cu alloy extracts, and bacterial survival rate was evaluated. The changes of bacterial biofilm and its structure were revealed by scanning electron microscopy (SEM) and transmission electronic microscopy (TEM), respectively. The results showed that the Mg-Cu alloy could significantly decrease the survival rates of bothP. gingivalisandA. actinomycetemcomitans. Furthermore, the bacterial biofilms were completely destroyed in Mg-Cu alloy extracts, and the bacterial cell membranes were damaged, finally leading to bacterial apoptosis. These results indicate that the Mg-Cu alloy can effectively eliminate periodontal pathogens, and the use of Mg-Cu in periodontal bone grafts has a great potential to prevent infections after periodontal surgery.
资助项目	Talents Plant for Liaoning Development[XLYC1802129] ; Natural Science Foundation of China[51631009] ; Research Start-Up Funds of DGUT[GC300501-082]
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000570898700002
资助机构	Talents Plant for Liaoning Development ; Natural Science Foundation of China ; Research Start-Up Funds of DGUT
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/140576]
专题	金属研究所_中国科学院金属研究所
通讯作者	Yang, Ke; Pan, Yaping
作者单位	1.China Med Univ, Sch & Hosp Stomatol, Dept Oral Biol, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 3.Dongguan Univ Technol, Sch Mat Sci & Engn, Dongguan 523808, Guangdong, Peoples R China 4.China Med Univ, Sch & Hosp Stomatol, Dept Periodont, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Xue,Wan, Peng,Wang, Hongyan,et al. An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics[J]. BIOMED RESEARCH INTERNATIONAL,2020,2020:9.
APA	Zhao, Xue.,Wan, Peng.,Wang, Hongyan.,Zhang, Shuwei.,Liu, Jingbo.,...&Pan, Yaping.(2020).An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics.BIOMED RESEARCH INTERNATIONAL,2020,9.
MLA	Zhao, Xue,et al."An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics".BIOMED RESEARCH INTERNATIONAL 2020(2020):9.