Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration

doi:10.1021/acs.bioconjchem.0c00201

CORC > 金属研究所 > 中国科学院金属研究所

	Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration
	Cai, Bianyun 4; Tan, Peijie 5,6,7; Jiang, Nan 5,6,7; Guo, Zhijun 1; Ay, Birol 8; Li, Shujun 3; Hou, Yi 4; Li, Yubao 4; You, Yanjun 2; Zhang, Li 4,5,6,7
刊名	BIOCONJUGATE CHEMISTRY
	2020-06-01
卷号	31 期号:6 页码:1641-1650
ISSN号	1043-1802
DOI	10.1021/acs.bioconjchem.0c00201
通讯作者	Zhang, Li(zhangli9111@126.com) ; Zhu, Songsong(zss_1977@163.com)
英文摘要	Bioinspired by the morphology of osteoclast-resorbed bone surfaces, we prepared a calcium-doped titanium phosphate (Ca-TiP) coating, which consists of a nanofibrous network, on titanium (Ti) substrate via a simple two-step hydrothermal method, trying to mimic natural bone compositionally and microstructurally. The in vitro studies show that the Ca-TiP coating with synergistic features of nanofibrous biomimetic topography and surface chemistry could elicit intensively osteogenic behavior and responses including enhanced cell adhesion, spreading, and proliferation as well as alkaline phosphatase (ALP) activity and up-regulated expression of bone-related genes, which inevitably benefit the formation of new bone and the quality of osseointegration. When the two control groups are compared in vivo, the significantly improved new bone formation in the early stage and the much stronger interfacial bonding with the surrounding bone for Ca-TiP coating suggest that Ca-TiP coating modified Ti implants hold great potential for orthopedic and dental applications.
资助项目	National Natural Science Foundation of China[51673131] ; National Natural Science Foundation of China[51871220] ; National Key Research and Development Program of China[2016YFA0201703] ; Key Research of Frontier Sciences, CAS[QYZDJ-SSW-JSC031-02]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000542926300008
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Key Research of Frontier Sciences, CAS
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/139455]
专题	金属研究所_中国科学院金属研究所
通讯作者	Zhang, Li; Zhu, Songsong
作者单位	1.China Univ Min & Technol, Sch Mat Sci & Phys, Xuzhou 221116, Jiangsu, Peoples R China 2.Sichuan Inst Food & Drug Control, Chengdu 610065, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.Sichuan Univ, Analyt & Testing Ctr, Chengdu 610065, Peoples R China 5.Sichuan Univ, State Key Lab Oral Dis, Chengdu 610065, Peoples R China 6.Sichuan Univ, Natl Clin Res Ctr Oral Dis, Chengdu 610065, Peoples R China 7.Sichuan Univ, West China Hosp Stomatol, Chengdu 610065, Peoples R China 8.Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
推荐引用方式 GB/T 7714	Cai, Bianyun,Tan, Peijie,Jiang, Nan,et al. Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration[J]. BIOCONJUGATE CHEMISTRY,2020,31(6):1641-1650.
APA	Cai, Bianyun.,Tan, Peijie.,Jiang, Nan.,Guo, Zhijun.,Ay, Birol.,...&Zhu, Songsong.(2020).Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration.BIOCONJUGATE CHEMISTRY,31(6),1641-1650.
MLA	Cai, Bianyun,et al."Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration".BIOCONJUGATE CHEMISTRY 31.6(2020):1641-1650.