Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity

doi:10.1016/j.jmst.2019.12.019

CORC > 金属研究所 > 中国科学院金属研究所

	Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity
	Liu, Hui 1,2; Liu, Rui 2,3; Ullah, Ihsan 1,2; Zhang, Shuyuan 2; Sun, Ziqing 2; Ren, Ling 2; Yang, Ke 2
刊名	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
	2020-07-01
卷号	48 页码:130-139
关键词	Titanium Copper Roughness surface Osteogenesis Antibacterial
ISSN号	1005-0302
DOI	10.1016/j.jmst.2019.12.019
通讯作者	Ren, Ling(lren@imr.ac.cn)
英文摘要	Implant-related infection and early bone integration are the main risk factors of implants for long-term service, to overcome these difficulties, SLA-TiCu surface was prepared by sandblasting and large-grits etching (SLA) treatment on a novel antibacterial titanium-copper alloy (TiCu), which is the most prevalent surface treatment with micro/submicron hierarchical structures to titanium-based implants. Effects of SLA-TiCu surface on the adhesion, proliferation, apoptosis and differentiation of MC3T3-E1 cells as well as the antibacterial activity against a common orthopedic pathogen (Staphylococcus aureus) were studied. Compared to the following surfaces: sandblasting and large-grits etched pure titanium (SLA-Ti), mechanically ground pure titanium and TiCu alloy (M-Ti and M-TiCu), these results indicated that SLA-TiCu surface obviously enhanced the bone-related gene expressions (alkaline phosphates (ALP), collagen type I (COL I), Runt-related transcription factor 2 (RUN x 2), and osteopontin (OPN)). Moreover, SLA-TiCu surface could maintain a sustainable release of Cu2+ ions and effectively inhibited the viability of bacteria. This study demonstrated that SLA-TiCu surface possessed multifunctional characteristics of improved osteogenic ability and antibacterial activity, making it promising as a novel implant material for hard tissue repairs such as orthopedics and dental implants. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
资助项目	National Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100601] ; LiaoNing Revitalization Talents Program[XLYC1807069] ; National Natural Science Foundation[51631009] ; National Natural Science Foundation[31870954] ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences[174321KYSB2018000]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
语种	英语
出版者	JOURNAL MATER SCI TECHNOL
WOS记录号	WOS:000534323200017
资助机构	National Key Research and Development Program of China ; LiaoNing Revitalization Talents Program ; National Natural Science Foundation ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/138965]
专题	金属研究所_中国科学院金属研究所
通讯作者	Ren, Ling
作者单位	1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China 3.Renji Hosp, State Key Lab Oncogenes & Related Genes, Inst Mol Med, 160 Pujian Rd, Shanghai 220127, Peoples R China
推荐引用方式 GB/T 7714	Liu, Hui,Liu, Rui,Ullah, Ihsan,et al. Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2020,48:130-139.
APA	Liu, Hui.,Liu, Rui.,Ullah, Ihsan.,Zhang, Shuyuan.,Sun, Ziqing.,...&Yang, Ke.(2020).Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,48,130-139.
MLA	Liu, Hui,et al."Rough surface of copper-bearing titanium alloy with multifunctions of osteogenic ability and antibacterial activity".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 48(2020):130-139.