Materials evolution of bone plates for internal fixation of bone fractures: A review

doi:10.1016/j.jmst.2019.07.024

CORC > 金属研究所 > 中国科学院金属研究所

	Materials evolution of bone plates for internal fixation of bone fractures: A review
	Li, Junlei 2; Qin, Ling 1,3; Yang, Ke 4; Ma, Zhijie 2; Wang, Yongxuan 2; Cheng, Liangliang 2; Zhao, Dewei 2
刊名	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
	2020
卷号	36 页码:190-208
关键词	Bone plate Biomaterials Biodegradable materials Titanium Magnesium Porous tantalum
ISSN号	1005-0302
DOI	10.1016/j.jmst.2019.07.024
通讯作者	Zhao, Dewei(zhaodewei2016@163.com)
英文摘要	Bone plates play a vital role in bone fracture healing by providing the necessary mechanical fixation for fracture fragments through modulating biomechanical microenvironment adjacent to the fracture site. Good treatment effect has been achieved for fixation of bone fracture with conventional bone plates, which are made of stainless steel or titanium alloy. However, several limitations still exist with traditional bone plates including loosening and stress shielding due to significant difference in modulus between metal material and bone tissue that impairs optimal fracture healing. Additionally, due to demographic changes and non-physiological loading, the population suffering from refractory fractures, such as osteoporosis fractures and comminuted fractures, is increasing, which imposes a big challenge to traditional bone plates developed for normal bone fracture repair. Therefore, optimal fracture treatment with adequate fixation implants in terms of materials and design relevant to special conditions is desirable. In this review, the complex physiological process of bone healing is introduced, followed by reviewing the development of implant design and biomaterials for bone plates. Finally, we discuss recent development of hybrid bone plates that contains bioactive elements or factors for fracture healing enhancement as a promising direction. This includes biodegradable Mg-based alloy used for designing bone screw-plates that has been proven to be beneficial for fracture healing, an innovative development that attracts more and more attention. This paper also indicates that the tantalum bone plates with porous structure are also emerging as a new fracture internal fixation implants. The reduction of the stress shielding is verified to be useful to accelerate bone fracture healing. Potential application of biodegradable metals may also avoid a second operation for implant removal. Further developments in biometals and their design for orthopedic bone plates are expected to improve the treatment of bone fracture, especially the refractory fractures. (C) 2019 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
资助项目	National Key R&D Programof China[2016YFC1102000] ; National Natural Science Foundation of China[81672139] ; National Natural Science Foundation of China[81702129] ; China Postdoctoral Science Foundation[171479] ; Doctor Initial Foundation of Liaoning Province[20170520017] ; Affiliated Zhongshan Hospital of Dalian University[DLDXZSYYDK201701] ; Research Grants Council of the Hong Kong Special Administrative Region, China[T13-402/17-N]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
语种	英语
出版者	JOURNAL MATER SCI TECHNOL
WOS记录号	WOS:000503162000024
资助机构	National Key R&D Programof China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Doctor Initial Foundation of Liaoning Province ; Affiliated Zhongshan Hospital of Dalian University ; Research Grants Council of the Hong Kong Special Administrative Region, China
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/136505]
专题	金属研究所_中国科学院金属研究所
通讯作者	Zhao, Dewei
作者单位	1.Chinese Acad Sci, Ctr Translat Med Res & Dev, Inst Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China 2.Dalian Univ, Dept Orthopaed, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China 3.Chinese Univ Hong Kong, Musculoskeletal Res Lab, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Li, Junlei,Qin, Ling,Yang, Ke,et al. Materials evolution of bone plates for internal fixation of bone fractures: A review[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2020,36:190-208.
APA	Li, Junlei.,Qin, Ling.,Yang, Ke.,Ma, Zhijie.,Wang, Yongxuan.,...&Zhao, Dewei.(2020).Materials evolution of bone plates for internal fixation of bone fractures: A review.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,36,190-208.
MLA	Li, Junlei,et al."Materials evolution of bone plates for internal fixation of bone fractures: A review".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 36(2020):190-208.