In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation

doi:10.1016/j.surfcoat.2019.06.023

CORC > 金属研究所 > 中国科学院金属研究所

	In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation
	Chen, Lanyue 1,4; Yan, Xudong 2,3; Tan, Lili 3; Zheng, Bowen 1; Muhammed, Fenik Kaml 1; Yang, Ke 3; Liu, Yi 1
刊名	SURFACE & COATINGS TECHNOLOGY
	2019-09-25
卷号	374 页码:784-796
关键词	Bilayer coating Degradation behavior Antibacterial ability Osteoconductivity
ISSN号	0257-8972
DOI	10.1016/j.surfcoat.2019.06.023
通讯作者	Yang, Ke(kyang@imr.ac.cn) ; Liu, Yi(liuyi@cmu.edu.cn)
英文摘要	A novel bio-functional calcium phosphate and magnesium (CaP-Mg) bilayer coating on titanium (Ti) was fabricated and characterized in vitro and in vivo. The bilayer coating was fabricated by biomimetic method and physical vapor deposition (PVD). The intermediate calcium phosphate (CaP) layer was mainly composed of octacalcium phosphate (OCP) and hydroxyapatite (HA). Compared to the single magnesium (Mg) coating, Mg layer on bilayer coating was thicker, coarser and porous. Immersion test and electrochemical test showed that the intermediate CaP layer could not decrease the degradation rate, however, inhibit detachment of Mg. The Mg coating delaminated from the single Mg coated sample following immersion for 1 day, while no obvious evidence of detachment was observed for the bilayer even after immersion for 14 days. In vitro antibacterial assays proved that the CaP-Mg coating strongly reduced the viability of Staphylococcus aureus and performed an about 90% antibacterial efficacy after 3 h incubation due to high alkalinity produced by the degradation of Mg. The bare Ti bar and coated Ti bar implants were implanted into New Zealand white rabbit lower jaws for 4 and 12 weeks, respectively. Cone beam computed tomography (CBCT), and Masson and hematoxyline-eosin (HE) staining showed CaP-Mg coated Ti bar promoted superior osteointegration after 4 and 12 weeks implantations.
资助项目	Liaoning Province Nature Science fund project[20180550420]
WOS研究方向	Materials Science ; Physics
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000486360000078
资助机构	Liaoning Province Nature Science fund project
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/135572]
专题	金属研究所_中国科学院金属研究所
通讯作者	Yang, Ke; Liu, Yi
作者单位	1.China Med Univ, Sch Stomatol, Dept Orthodont, Shenyang 110001, Liaoning, Peoples R China 2.Cent S Univ, Shoot Mat Sci & Engn, Changsha 410083, Hunan, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 4.Guilin Med Univ, Sch Stomatol, Dept Orthodont, Guilin 541001, Peoples R China
推荐引用方式 GB/T 7714	Chen, Lanyue,Yan, Xudong,Tan, Lili,et al. In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation[J]. SURFACE & COATINGS TECHNOLOGY,2019,374:784-796.
APA	Chen, Lanyue.,Yan, Xudong.,Tan, Lili.,Zheng, Bowen.,Muhammed, Fenik Kaml.,...&Liu, Yi.(2019).In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation.SURFACE & COATINGS TECHNOLOGY,374,784-796.
MLA	Chen, Lanyue,et al."In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation".SURFACE & COATINGS TECHNOLOGY 374(2019):784-796.