Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants

doi:10.1002/jbm.b.34332

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	Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants
	Du, Zhe 1,3; Yu, Xiaoming 2; Nie, Binen 3; Zhu, Zhonglin 4; Ibrahim, Muhammad 2,5; Yang, Ke 2; Tan, Lili 2; Wang, You 3
刊名	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
	2019-10-01
卷号	107 期号:7 页码:2388-2396
关键词	magnesium osteolysis polyether-ether-ketone particles rabbit model Ti6Al4V implant
ISSN号	1552-4973
DOI	10.1002/jbm.b.34332
通讯作者	Tan, Lili(lltan@imr.ac.cn) ; Wang, You(drwangyou@126.com)
英文摘要	We investigated the effects of magnesium (Mg) on osteogenesis and bone resorption at a porous structure interface. A three-dimensional (3D)-printed porous Ti6Al4V implant coated with Mg was introduced, and polyether-ether-ketone wear particles were added to generate an animal model of implant loosening. We also examined the effects of Mg leach liquor on osteoblast/osteoclast gene expression, alkaline phosphatase activity, collagen secretion, tartrate-resistant acid phosphatase activity, and bone resorption in vitro. Mg inhibited the early stage of osteoclast differentiation and inhibited bone resorption in vitro and in vivo. However, Mg did not enhance osteogenesis in vitro or in vivo in the porous structures or in peripheral areas around the implants. For implants with porous structures, the Mg coating did not improve the osteogenic ability by itself, but could restrain peri-implant osteolysis, which may make it favorable for use in patients with osteoporosis. Further studies are needed to examine the precise mechanism of Mg-induced anti-osteolysis and the long-term effects of Mg-coated implants in humans. (c) 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2388-2396, 2019.
资助项目	National Key R&D Program of China[2016YFC1101802] ; National Key R&D Program of China[2016YFC1101804] ; National Key R&D Program of China[2016YFC1]
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000483702000019
资助机构	National Key R&D Program of China
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/135384]
专题	金属研究所_中国科学院金属研究所
通讯作者	Tan, Lili; Wang, You
作者单位	1.Peking Univ, Peoples Hosp, Trauma Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Bone & Joint Surg, Shanghai, Peoples R China 4.Jiangsu OKANI Med Technol Co Ltd, Suzhou, Peoples R China 5.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Du, Zhe,Yu, Xiaoming,Nie, Binen,et al. Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2019,107(7):2388-2396.
APA	Du, Zhe.,Yu, Xiaoming.,Nie, Binen.,Zhu, Zhonglin.,Ibrahim, Muhammad.,...&Wang, You.(2019).Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,107(7),2388-2396.
MLA	Du, Zhe,et al."Effects of magnesium coating on bone-implant interfaces with and without polyether-ether-ketone particle interference: A rabbit model based on porous Ti6Al4V implants".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 107.7(2019):2388-2396.