In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect

doi:10.1016/j.jmst.2019.04.031

CORC > 金属研究所 > 中国科学院金属研究所

	In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect
	Chen, Junxiu 1,2; Dong, Jiahui 1,2; Fu, Huameng 1; Zhang, Haifeng 1; Tan, Lili 1; Zhao, Dewei 3; Yang, Ke 1
刊名	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
	2019-10-01
卷号	35 期号:10 页码:2254-2262
关键词	Mg69Zn27Ca4 metal glass Degradation Cytocompatibility Bone substitutes
ISSN号	1005-0302
DOI	10.1016/j.jmst.2019.04.031
通讯作者	Tan, Lili(lltan@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
英文摘要	In the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank's solution. In vitro cytotoxicity test showed that Mg(69)Zn(27)Ca(4 )metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original phi 6 mm to phi 3.35 +/- 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. (C) 2019 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
资助项目	Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1101804] ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1100604] ; Shenyang Key Research & Development and Technology Transfer Program[Z18-0-027]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
语种	英语
出版者	JOURNAL MATER SCI TECHNOL
WOS记录号	WOS:000484531600019
资助机构	Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement ; Shenyang Key Research & Development and Technology Transfer Program
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/135150]
专题	金属研究所_中国科学院金属研究所
通讯作者	Tan, Lili; Yang, Ke
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China 3.Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China
推荐引用方式 GB/T 7714	Chen, Junxiu,Dong, Jiahui,Fu, Huameng,et al. In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2019,35(10):2254-2262.
APA	Chen, Junxiu.,Dong, Jiahui.,Fu, Huameng.,Zhang, Haifeng.,Tan, Lili.,...&Yang, Ke.(2019).In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,35(10),2254-2262.
MLA	Chen, Junxiu,et al."In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 35.10(2019):2254-2262.