Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graf Restenosis

doi:10.3349/ymj.2019.60.5.429

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	Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graf Restenosis
	Li, Yugang 1; Wang, Lei 1; Chen, Shanshan 2; Yu, Dan 1; Sun, Weifeng 1; Xin, Shijie 1
刊名	YONSEI MEDICAL JOURNAL
	2019-05-01
卷号	60 期号:5 页码:429-439
关键词	Restenosis vascular graft biodegradable stent magnesium
ISSN号	0513-5796
DOI	10.3349/ymj.2019.60.5.429
通讯作者	Xin, Shijie(sjxin@cmu.edu.cn)
英文摘要	Purpose: To explore the effects of biodegradable magnesium alloy stents (BMAS) on remodeling of vein graft (VG) anastomotic restenosis. Materials and Methods: To establish a VG restenosis model, seventy two New Zealand rabbits were randomly divided into three groups according to whether a stent was implanted in the graft vein or not. BMASs and 316L stainless steel stents were implanted in BMAS and 316L groups, respectively, while no stent was implanted in the no-treatment control group (NC group). Loss of lumen diameter in the graft vein was measured in all three groups. Upon harvesting VG segments to evaluate intimal proliferation and re-endothelization, the degradation and biological safety of the stents were observed to explore the effects of BMAS on VG remodeling. Results: Model establishment and stent implantation were successful. The BMAS reduced lumen loss, compared with the control group (0.05 +/- 0.34 mm vs. 0.90 +/- 0.39 mm, p=0.001), in the early stage. The neointimal area was smaller in the BMAS group than the 316L group after 4 months (4.96 +/- 0.66 mm(2) vs. 6.80 +/- 0.69 mm(2), p=0.017). Re-endothelialization in the BMAS group was better than that in the 316L group (p=0.001). Within 4 months, the BMAS had degraded, and the magnesium was converted to phosphorus and calcium. The support force of the BMAS began to reduce at 2-3 months after implantation, without significant toxic effects. Conclusion: BMAS promotes positive remodeling of VG anastomosis and has advantages over the conventional 316L stents in the treatment of venous diseases.
资助项目	National Natural Science Foundation of China[81000136]
WOS研究方向	General & Internal Medicine
语种	英语
出版者	YONSEI UNIV COLL MEDICINE
WOS记录号	WOS:000465448300005
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/133111]
专题	金属研究所_中国科学院金属研究所
通讯作者	Xin, Shijie
作者单位	1.China Med Univ, Affiliated Hosp 1, Dept Vasc & Thyroid Surg, Shenyang 110001, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Li, Yugang,Wang, Lei,Chen, Shanshan,et al. Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graf Restenosis[J]. YONSEI MEDICAL JOURNAL,2019,60(5):429-439.
APA	Li, Yugang,Wang, Lei,Chen, Shanshan,Yu, Dan,Sun, Weifeng,&Xin, Shijie.(2019).Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graf Restenosis.YONSEI MEDICAL JOURNAL,60(5),429-439.
MLA	Li, Yugang,et al."Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graf Restenosis".YONSEI MEDICAL JOURNAL 60.5(2019):429-439.