Enantioselective Elimination and Gonadal Disruption of Lambda-Cyhalothrin on Lizards (Eremias argus)

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院环境生物技术重点实验室

	Enantioselective Elimination and Gonadal Disruption of Lambda-Cyhalothrin on Lizards (Eremias argus)
	Chang, Jing; Xu, Peng; Li, Wei; Li, Jitong; Wang, Huili
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2019-02-27
卷号	67 期号:8 页码:2183-2189
关键词	pyrethroid pesticides endocrine disruption metabolism enantiomers reptiles
ISSN号	0021-8561
英文摘要	In this study, the different metabolic pathways of lambda-cyhalothrin (LCT) enantiomers in Eremias argus feces and enantioselective disruption on hypothalamus-pituitary-gonad (HPG) system were investigated. After 7 days oral exposure to LCT enantiomers, the concentration of 3-phenoxybenzoic acid (PBA), hydroxylated and sulfated LCT were higher in the (+)-LCT exposure group than that in the (-)-LCT exposure group, which indicated a higher metabolic rate of (+)-LCT than (-)-LCT. Although no significant differences were seen on lizard body weight after enantiomers' exposure, the gonadosomatic index was dramatically decreased. The testicular impacts such as increased seminiferous tubule diameters were only observed in the (+)-LCT exposure group. Consistent with this result, the expression of ar gene in the (+)-LCT exposure was significantly higher than that in the (-)-LCT exposure group. In addition, the stronger binding affinity of AR with (+)-LCT further demonstrated the more serious disruption of (+)-LCT on lizard HPG axis than (-)-LCT. This study first elucidated the metabolic pathway and endocrine effects of LCT in lizards at enantiomeric level and provided some evidence for lizard population decline.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/43363]
专题	生态环境研究中心_中国科学院环境生物技术重点实验室
作者单位	Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Shuangqing Rd 18, Beijing 100085, Peoples R China
推荐引用方式 GB/T 7714	Chang, Jing,Xu, Peng,Li, Wei,et al. Enantioselective Elimination and Gonadal Disruption of Lambda-Cyhalothrin on Lizards (Eremias argus)[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2019,67(8):2183-2189.
APA	Chang, Jing,Xu, Peng,Li, Wei,Li, Jitong,&Wang, Huili.(2019).Enantioselective Elimination and Gonadal Disruption of Lambda-Cyhalothrin on Lizards (Eremias argus).JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,67(8),2183-2189.
MLA	Chang, Jing,et al."Enantioselective Elimination and Gonadal Disruption of Lambda-Cyhalothrin on Lizards (Eremias argus)".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 67.8(2019):2183-2189.