Relationship between perfluorooctanoate and perfluorooctane sulfonate blood concentrations in the general population and routine drinking water exposure

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境水质学国家重点实验室

	Relationship between perfluorooctanoate and perfluorooctane sulfonate blood concentrations in the general population and routine drinking water exposure
	Zhang, Shiyi ; Kang, Qiyue ; Peng, Hui ; Ding, Mengyu ; Zhao, Fanrong ; Zhou, Yuyin ; Dong, Zhaomin ; Zhang, Haifeng ; Yang, Min ; Tao, Shu
刊名	ENVIRONMENT INTERNATIONAL
	2019-05
卷号	126 页码:54-60
关键词	Perfluorinated compounds Criteria Human exposure Relative source contribution
ISSN号	0160-4120
英文摘要	human perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) exposure has been well documented. However, the relationship of PFOA/PFOS blood concentrations in the general population to routine drinking water exposure is not well characterized. This study determined the PFOA and PFOS concentrations in 166 drinking water samples across 28 cities in China. For 13 of the studied cities, PFOA and PFOS concentrations were analyzed in 847 human blood samples which were collected in parallel with the drinking water samples. The geometric mean PFOA and PFOS concentrations in drinking water were 2.5 +/- 6.2 ng/L and 0.7 +/- 11.7 ng/L, and population-weighted geometric mean blood concentrations were 2.1 +/- 1.2 ng/mL and 2.6 +/- 1.3 ng/mL, respectively. We found a significant correlation between the PFOA concentration in drinking water and blood (r = 0.87, n = 13, p < 0.001). The total daily intake of PFOA (0.24-2.13 ng/kg/day) and PFOS (0.19-1.87 ng/kg/day) were back-calculated from the blood concentrations with a one-compartment toxicokinetic model. We estimated relative source contributions (RSCs) of drinking water to total daily intake in China of 23 +/- 3% for PFOA and 12.7 +/- 5.8% for PFOS. Using the mean RSCs, we derived the health advisory values of 85 ng/L for PFOA and 47 ng/L for PFOS in China.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/43112]
专题	生态环境研究中心_环境水质学国家重点实验室
作者单位	1.Peking Univ, Coll Urban & Environm Sci, MOE Lab Earth Surface Proc, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China 3.Beihang Univ, Sch Space & Environm, Beijing 100191, Peoples R China 4.Univ Toronto, Dept Chem, Toronto, ON, Canada
推荐引用方式 GB/T 7714	Zhang, Shiyi,Kang, Qiyue,Peng, Hui,et al. Relationship between perfluorooctanoate and perfluorooctane sulfonate blood concentrations in the general population and routine drinking water exposure[J]. ENVIRONMENT INTERNATIONAL,2019,126:54-60.
APA	Zhang, Shiyi.,Kang, Qiyue.,Peng, Hui.,Ding, Mengyu.,Zhao, Fanrong.,...&Hu, Jianying.(2019).Relationship between perfluorooctanoate and perfluorooctane sulfonate blood concentrations in the general population and routine drinking water exposure.ENVIRONMENT INTERNATIONAL,126,54-60.
MLA	Zhang, Shiyi,et al."Relationship between perfluorooctanoate and perfluorooctane sulfonate blood concentrations in the general population and routine drinking water exposure".ENVIRONMENT INTERNATIONAL 126(2019):54-60.