Radial extracorporeal shock wave promotes the enhanced permeability and retention effect to reinforce cancer nanothermotherapeutics

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Radial extracorporeal shock wave promotes the enhanced permeability and retention effect to reinforce cancer nanothermotherapeutics
	Yin, Chunyang ; Wang, Shunhao ; Ren, Quanzhong ; Shen, Xinming ; Chen, Xiaodong ; Liu, Yajun ; Liu, Sijin
刊名	SCIENCE BULLETIN
	2019-05-30
卷号	64 期号:10 页码:679-689
关键词	Radial extracorporeal shock wave Nanomedicine Nanothermotherapeutics Vasodilation Tumor perfusion
ISSN号	2095-9273
英文摘要	Since most cancer nanomedicine relies on the enhanced permeability and retention (EPR) effect to eradicate tumors, strategies that are able to promote nanoparticle (NP) delivery and extravasation are presupposed to elevate the EPR effect for more effective cancer therapeutics. However, nanothermotherapeutics still suffers from limited drug delivery into tumor sites, for even though numerous efforts have been made to enhance the selective tumor targeting of NPs. In this study, we uncovered that radial extracorporeal shock wave therapy (rESWT), an important approach in physical therapy that has been overlooked in cancer treatment in the past, can largely improve the EPR-dependent tumor uptake of NPs. We here defined the optimal low dosage and desirable combinatory manner for rESWT in driving NP accumulation towards tumors. Two underlying biophysical mechanisms responsible for the rESWT-enhanced EPR effect were proposed. On one hand, rESWT-conducted compressive and tensile forces could relieve high intra-tumoral pressure; on the other hand, rESWT-induced cavitation bubbles could directly distend and disrupt tumor blood vessels. All these together synergistically promoted vessel vasodilation, tumor perfusion and NP extravasation. Further experiments revealed that the combinatory therapeutics between rESWT and nanothermotherapeutics greatly improved the tumor-killing efficacy. Thus, our findings open a new path to improve EPR-mediated drug delivery with the assistance of rESWT. (C) 2019 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42999]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Beijing Jishuitan Hosp, Orthoped Shock Wave Treatment Ctr, Dept Spine Surg, Beijing 100035, Peoples R China 3.Beijing Inst Technol, Sch Aerosp Engn, Beijing 100081, Peoples R China 4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
推荐引用方式 GB/T 7714	Yin, Chunyang,Wang, Shunhao,Ren, Quanzhong,et al. Radial extracorporeal shock wave promotes the enhanced permeability and retention effect to reinforce cancer nanothermotherapeutics[J]. SCIENCE BULLETIN,2019,64(10):679-689.
APA	Yin, Chunyang.,Wang, Shunhao.,Ren, Quanzhong.,Shen, Xinming.,Chen, Xiaodong.,...&Liu, Sijin.(2019).Radial extracorporeal shock wave promotes the enhanced permeability and retention effect to reinforce cancer nanothermotherapeutics.SCIENCE BULLETIN,64(10),679-689.
MLA	Yin, Chunyang,et al."Radial extracorporeal shock wave promotes the enhanced permeability and retention effect to reinforce cancer nanothermotherapeutics".SCIENCE BULLETIN 64.10(2019):679-689.