Design, synthesis, and evaluation of alpha-galactopyranosylceramide mimics promoting Th2 cytokines production

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Design, synthesis, and evaluation of alpha-galactopyranosylceramide mimics promoting Th2 cytokines production
	Hu, Liyan ; Zhao, Chuanfang ; Ma, Juan ; Jing, Yang ; Du, Yuguo
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2019-06-01
卷号	29 期号:11 页码:1357-1362
关键词	KRN7000 OCH CD1d Th2 cytokines NKT cells
ISSN号	0960-894X
英文摘要	The binding properties of CD1d/glycolipid/TCR, glycolipid/TCR interactions in particular, have been investigated using docking computation. Accordingly, efficient modification on C-6' of galactose head was recommended in this report to favor the production of Th2 cytokines. The designed glycolipids have been successfully prepared taking advantages of inverse glycosylation procedure, and their abilities to stimulate mouse iNKT cells in vivo have been tested. Compound 9, having p-hydroxyphenylpropionyl amide group on C-6', presented the best result with respect to the selectivity and quantity on Th2-type cytokine IL-4. We found that the increased glycolipid/TCR interaction might be critical in designing new substrate with Th2-biased cytokine production.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42925]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
推荐引用方式 GB/T 7714	Hu, Liyan,Zhao, Chuanfang,Ma, Juan,et al. Design, synthesis, and evaluation of alpha-galactopyranosylceramide mimics promoting Th2 cytokines production[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2019,29(11):1357-1362.
APA	Hu, Liyan,Zhao, Chuanfang,Ma, Juan,Jing, Yang,&Du, Yuguo.(2019).Design, synthesis, and evaluation of alpha-galactopyranosylceramide mimics promoting Th2 cytokines production.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,29(11),1357-1362.
MLA	Hu, Liyan,et al."Design, synthesis, and evaluation of alpha-galactopyranosylceramide mimics promoting Th2 cytokines production".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 29.11(2019):1357-1362.