Effect of methyl tert-butyl ether on adipogenesis and glucose metabolism in vitro and in vivo

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Effect of methyl tert-butyl ether on adipogenesis and glucose metabolism in vitro and in vivo
	Tang, Yue 1; Ren, Qidong 1; Wen, Qing 1; Yu, Caixia 1; Xie, Xinni ; Hu, Qing 2; Du, Yuguo 1
刊名	JOURNAL OF ENVIRONMENTAL SCIENCES
	2019-11-01
卷号	85 页码:208-219
关键词	MTBE Adipogenesis Glucose metabolism Metabolic disorder Gut microbiota
ISSN号	1001-0742
英文摘要	Methyl tert-butyl ether (MTBE), as a widely used gasoline additive, is suspected of being environmentally toxic. MTBE accumulates mainly in adipose tissue, but its effect on obesity or obesity-related metabolic disorders has not been well understood yet. Therefore, we examined the effect of MTBE on the adipose function and the related metabolic processes with both 3T3-L1 cell line and C57BL/6J mice model. We found that exposure to MTBE at the environmental relevant concentration (100 mu mol/L) could significantly induce differentiation of preadipocyte and disturb insulin-stimulated glucose uptake of mature adipocyte. The in vivo observation in male mice showed a positive correlation of visceral white adipose tissue (vWAT) expansion and cell size increase with MTBE treatment in 14 weeks. Glucose tolerance and insulin sensitivity tests demonstrated that MTBE at 1000 mu g/(kg.day) disturbed the systemic glucose metabolism in a gender-specific manner, which might be partly attributed to the alterations of gut microbiota community at genus level with respect to Akkermansia, Clostridium XlVb, and Megamonas. In summary, our study characterized the effect of MTBE on adipose tissue function and glucose homeostasis in vitro and in vivo, and revealed that systemic disorders of the glucose metabolism might be modulated by the related gut microbiota. (c) 2019 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42532]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China 3.Southern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
推荐引用方式 GB/T 7714	Tang, Yue,Ren, Qidong,Wen, Qing,et al. Effect of methyl tert-butyl ether on adipogenesis and glucose metabolism in vitro and in vivo[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2019,85:208-219.
APA	Tang, Yue.,Ren, Qidong.,Wen, Qing.,Yu, Caixia.,Xie, Xinni.,...&Du, Yuguo.(2019).Effect of methyl tert-butyl ether on adipogenesis and glucose metabolism in vitro and in vivo.JOURNAL OF ENVIRONMENTAL SCIENCES,85,208-219.
MLA	Tang, Yue,et al."Effect of methyl tert-butyl ether on adipogenesis and glucose metabolism in vitro and in vivo".JOURNAL OF ENVIRONMENTAL SCIENCES 85(2019):208-219.