Combination of sulfonamides, silver antimicrobial agents and quorum sensing inhibitors as a preferred approach for improving antimicrobial efficacy against Bacillus subtilis

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Combination of sulfonamides, silver antimicrobial agents and quorum sensing inhibitors as a preferred approach for improving antimicrobial efficacy against Bacillus subtilis
	Yu, Haiyan ; Sun, Haoyu 1,2,3,4; Yin, Chunsheng ; Lin, Zhifen 1,2,3,5
刊名	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
	2019-10-15
卷号	181 页码:43-48
关键词	Combined toxicity Sulfonamides Silver antibacterial agents Quorum sensing inhibitors B. subtilis
ISSN号	0147-6513
英文摘要	More and more antibacterial agents are used together to treat bacterial infections in diverse fields, but the overuse of antibacterial agents may cause the environmental pollution of antibiotic resistance genes (ARGs). In order to reduce the use of antimicrobial agents, the potential joint effects of quorum-sensing inhibitors (QSIs) and traditional antimicrobial agents have been proposed to be effective. In this study, the joint effects of traditional antimicrobial agents, represented by sulfonamides (SAs) and silver antibacterial agents (silver nitrate (AgNO3) and nanosilver (AgNP, 5 nm)), and five potential QSIs, were investigated using B. subtilis. It was found that AgNP showed higher toxicity than AgNO3, whereas the joint effects on B. subtilis showed no difference between AgNO3 and AgNP when they combined with SAs or QSIs, respectively. In general, AgNO3 and AgNP presented synergetic and additive effects with QSIs, but additive and antagonistic effects with SAs; SAs exhibited synergetic, additive and antagonistic effects with different QSIs whether in binary or ternary mixed system. Moreover, it was found that the use of antimicrobials was reduced and the synergistic combined toxicity of antimicrobial agents on B. subtilis was increased through the addition of the QSIs. This study can offer a valuable reference for the combined medication of the different antimicrobial agents, which will benefit the environmental and human health.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42523]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Shanghai Ocean Univ, Coll Marine Ecol & Environm, Shanghai 201306, Peoples R China 2.Tongji Univ, Coll Environm Sci & Engn, State Key Lab Pollut Control & Resource Reuse, Shanghai 200092, Peoples R China 3.Shanghai Inst Pollut Control & Ecol Secur, Shanghai 200092, Peoples R China 4.Shanghai Key Lab Chem Assessment & Sustainabil, Shanghai 200092, Peoples R China 5.Tongji Univ, Coll Civil Engn, Postdoctoral Res Stn, Shanghai 200092, Peoples R China 6.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
推荐引用方式 GB/T 7714	Yu, Haiyan,Sun, Haoyu,Yin, Chunsheng,et al. Combination of sulfonamides, silver antimicrobial agents and quorum sensing inhibitors as a preferred approach for improving antimicrobial efficacy against Bacillus subtilis[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,181:43-48.
APA	Yu, Haiyan,Sun, Haoyu,Yin, Chunsheng,&Lin, Zhifen.(2019).Combination of sulfonamides, silver antimicrobial agents and quorum sensing inhibitors as a preferred approach for improving antimicrobial efficacy against Bacillus subtilis.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,181,43-48.
MLA	Yu, Haiyan,et al."Combination of sulfonamides, silver antimicrobial agents and quorum sensing inhibitors as a preferred approach for improving antimicrobial efficacy against Bacillus subtilis".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 181(2019):43-48.