Tissue-Specific Accumulation and Antioxidant Defenses in Flounder (Paralichthys olivaceus) Juveniles Experimentally Exposed to Methylmercury

doi:10.1007/s00244-020-00775-2

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	Tissue-Specific Accumulation and Antioxidant Defenses in Flounder (Paralichthys olivaceus) Juveniles Experimentally Exposed to Methylmercury
	Ren, Zhonghua 1,3; Liu, Jinhu 1,2; Dou, Shuozeng 1,2,5; Zhou, Dayan 4; Cui, Wenting 1,5; Lv, Zhenbo 3; Cao, Liang 1,2
刊名	ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
	2020-10-29
页码	15
ISSN号	0090-4341
DOI	10.1007/s00244-020-00775-2
通讯作者	Lv, Zhenbo(ytlvzhenbo@163.com) ; Cao, Liang(caoliang@qdio.ac.cn)
英文摘要	Methylmercury (MeHg) is the most toxic form of mercury and can accumulate in the cells of marine organisms, such as fish, causing adverse effects on various physiological functions. This study examined MeHg accumulation and its toxicological role in antioxidant defenses in tissues, including the liver, gills, and muscle of flounder (Paralichthys olivaceus) juveniles. After 30 d of MeHg exposure (0, 0.1, 1.0, 10.0, and 20.0 mu g L-1), the accumulation of MeHg in the three tissues correlated positively with the concentration of MeHg and exhibited tissue specificity in the order of liver > gills > muscle. Among the antioxidant markers, the activities of SOD (superoxide dismutase) and GST (glutathione S-transferase) as well as the content of glutathione (GSH) in the liver and gills were induced at 0.1-10.0 mu g L-1 but repressed at 20.0 mu g L-1. The activities of SOD and GST and the content of GSH in the muscle significantly increased with increasing MeHg concentration. Catalase (CAT) activity in the liver was induced at 0.1-1.0 mu g L-1 but inhibited at 10.0-20.0 mu g L-1, whereas exposure to MeHg did not remarkably affect CAT activity in the gills and muscle. The levels of lipid peroxidation (LPO) increased dose dependently, showing tissue specificity with the highest level in the liver, then the gills, followed by muscles. Overall, higher sensitivity to oxidative stress induced by MeHg was detected in the liver than the gills and muscle. These findings improve our understanding of the tissue-specific accumulation of heavy metals and their roles in antioxidant responses in marine fish subjected to MeHg exposure.
资助项目	Major Science and Technology Innovation Projects of Shandong Province[2018SDKJ0501-1] ; National Natural Science Foundation of China (NSFC)[41406167] ; NSFC-Shandong Joint Fund for Marine Science Research Center[U1606404]
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000584999400001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/169075]
专题	海洋研究所_海洋生态与环境科学重点实验室
通讯作者	Lv, Zhenbo; Cao, Liang
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 3.Ludong Univ, Sch Resource & Environm Engn, Inst Adv Study Coastal Ecol, Yantai 264000, Peoples R China 4.Aquat Species Intro & Breeding Ctr Guangxi, Nanning 530031, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Ren, Zhonghua,Liu, Jinhu,Dou, Shuozeng,et al. Tissue-Specific Accumulation and Antioxidant Defenses in Flounder (Paralichthys olivaceus) Juveniles Experimentally Exposed to Methylmercury[J]. ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2020:15.
APA	Ren, Zhonghua.,Liu, Jinhu.,Dou, Shuozeng.,Zhou, Dayan.,Cui, Wenting.,...&Cao, Liang.(2020).Tissue-Specific Accumulation and Antioxidant Defenses in Flounder (Paralichthys olivaceus) Juveniles Experimentally Exposed to Methylmercury.ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,15.
MLA	Ren, Zhonghua,et al."Tissue-Specific Accumulation and Antioxidant Defenses in Flounder (Paralichthys olivaceus) Juveniles Experimentally Exposed to Methylmercury".ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2020):15.