Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

doi:10.7554/eLife.53370

CORC > 海洋研究所 > 中国科学院海洋研究所 > 海洋生态与环境科学重点实验室

	Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species
	Wang, Tianming 4,5; Cao, Zheng 2; Shen, Zhangfei 2; Yang, Jingwen 4,5; Chen, Xu 4; Yang, Zhen 4; Xu, Ke 4; Xiang, Xiaowei 4; Yu, Qiuhan 4; Song, Yimin 4
刊名	ELIFE
	2020-06-09
卷号	9 页码:28
ISSN号	2050-084X
DOI	10.7554/eLife.53370
通讯作者	Wang, Tianming(wangtianming@zjou.edu.cn) ; Zhou, Naiming(zhounaiming@zju.edu.cn)
英文摘要	The kisspeptin system is a central modulator of the hypothalamic-pituitary-gonadal axis in vertebrates. Its existence outside the vertebrate lineage remains largely unknown. Here, we report the identification and characterization of the kisspeptin system in the sea cucumber Apostichopus japonicus. The gene encoding the kisspeptin precursor generates two mature neuropeptides, AjKiss1a and AjKiss1b. The receptors for these neuropeptides, AjKissR1 and AjKissR2, are strongly activated by synthetic A. japonicus and vertebrate kisspeptins, triggering a rapid intracellular mobilization of Ca2+, followed by receptor internalization. AjKissR1 and AjKissR2 share similar intracellular signaling pathways via G(alpha q)/PLC/PKC/MAPK cascade, when activated by C-terminal decapeptide. The A. japonicus kisspeptin system functions in multiple tissues that are closely related to seasonal reproduction and metabolism. Overall, our findings uncover for the first time the existence and function of the kisspeptin system in a non-chordate species and provide new evidence to support the ancient origin of intracellular signaling and physiological functions that are mediated by this molecular system.
资助项目	National Science Foundation of China[41876154] ; National Science Foundation of China[41406137] ; National Science Foundation of China[41606150] ; Center for Ocean Mega-Research of Science, Chinese Acadamy of Science[COMS2019Q15]
WOS研究方向	Life Sciences & Biomedicine - Other Topics
语种	英语
出版者	ELIFE SCIENCES PUBLICATIONS LTD
WOS记录号	WOS:000541447600001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/167765]
专题	海洋研究所_海洋生态与环境科学重点实验室
通讯作者	Wang, Tianming; Zhou, Naiming
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China 2.Zhejiang Univ, Coll Life Sci, Inst Biochem, Zijingang Campus, Hangzhou, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 4.Zhejiang Ocean Univ, Marine Sci Coll, Natl Engn Res Ctr Marine Facil Aquaculture, Zhoushan, Peoples R China 5.Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, Programs Human Genet & Biol Sci, San Francisco, CA 94143 USA
推荐引用方式 GB/T 7714	Wang, Tianming,Cao, Zheng,Shen, Zhangfei,et al. Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species[J]. ELIFE,2020,9:28.
APA	Wang, Tianming.,Cao, Zheng.,Shen, Zhangfei.,Yang, Jingwen.,Chen, Xu.,...&Zhou, Naiming.(2020).Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species.ELIFE,9,28.
MLA	Wang, Tianming,et al."Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species".ELIFE 9(2020):28.