Review: Advances in preparation of chitooligosaccharides with heterogeneous sequences and their bioactivity

doi:10.1016/j.carbpol.2020.117206

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Review: Advances in preparation of chitooligosaccharides with heterogeneous sequences and their bioactivity
	Hao, Wentong 1,2,3; Li, Kecheng 1,3; Li, Pengcheng 1,3
刊名	CARBOHYDRATE POLYMERS
	2021-01-15
卷号	252 页码:11
关键词	Chitooligosaccharides Heterogeneous sequences Chitin deacetylases Synthesis Preparation
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2020.117206
通讯作者	Li, Kecheng(lkc@qdio.ac.cn) ; Li, Pengcheng(pcli@qdio.ac.cn)
英文摘要	Chitooligosaccharides has attracted increasing attention due to their diverse bioactivities and potential application. Previous studies on the bioactivity of chitooligosaccharides were mostly carried out using a mixture. The structure-function relationship of chitooligosaccharides is not clear. Recently, it is confirmed that chitooligosaccharides with different degrees of polymerization play different roles in many bioactivities. However, heterogeneous chitooligosaccharides with a single degree of polymerization is still a mixture of many uncertain sequences and it is difficult to determine which structure is responsible for biological effects. Therefore, an interesting and challenging field of studying chitooligosaccharides with heterogeneous sequences has emerged. Herein, we reviewed the current methods for preparing heterogeneous chitooligosaccharides, including chemical synthesis, separation techniques and enzymatic methods. Advances in the bioactivities of chitooligosaccharides with heterogeneous sequences are also reviewed.
资助项目	National Natural Science Foundation of China[41976096,41406086] ; National Key R&D Program of China[2018YFC0311305,2019YFD0902105] ; Key Research and Development Program of Shandong Province[2019YYSP028]
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000596865100002
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/169542]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Li, Kecheng; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Hao, Wentong,Li, Kecheng,Li, Pengcheng. Review: Advances in preparation of chitooligosaccharides with heterogeneous sequences and their bioactivity[J]. CARBOHYDRATE POLYMERS,2021,252:11.
APA	Hao, Wentong,Li, Kecheng,&Li, Pengcheng.(2021).Review: Advances in preparation of chitooligosaccharides with heterogeneous sequences and their bioactivity.CARBOHYDRATE POLYMERS,252,11.
MLA	Hao, Wentong,et al."Review: Advances in preparation of chitooligosaccharides with heterogeneous sequences and their bioactivity".CARBOHYDRATE POLYMERS 252(2021):11.