Coral gasdermin triggers pyroptosis

doi:10.1126/sciimmunol.abd2591

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Coral gasdermin triggers pyroptosis
	Jiang, Shuai 1,2,3,5; Zhou, Zhi 4; Sun, Yuanyuan 1,2,3; Zhang, Tengfei 1,2,3,5; Sun, Li 1,2,3,5
刊名	SCIENCE IMMUNOLOGY
	2020-12-01
卷号	5 期号:54 页码:10
ISSN号	2470-9468
DOI	10.1126/sciimmunol.abd2591
通讯作者	Sun, Li(lsun@qdio.ac.cn)
英文摘要	Gasdermins are executioners of the inflammatory cell death pathway pyroptosis that has so far been studied exclusively in vertebrates. In this study, we identified gasdermin E (GSDME) homologs in several invertebrate species including corals. We report that coral GSDME was cleaved by caspase 3 at two sites, yielding two active isoforms of GSDME N-terminal domain that were capable of inducing pyroptosis. Ectopic coexpression of coral GSDME and caspase 3 in human cells promoted pyroptosis. Corals infected with Vibrio coralliilyticus, a bacterial pathogen causing rapid tissue necrosis of corals worldwide, exhibited necrotic death with elevated caspase 3 activity and GSDME cleavage, whereas inhibition of caspase 3 blocked GSDME cleavage and protected corals from necrotic death. These results indicate that functional gasdermin exists in invertebrates and that coral gasdermin is involved in pathogen-induced coral death. Furthermore, our studies also suggest that mediation of pyroptosis is an evolutionarily conserved function of gasdermins.
资助项目	National Natural Science Foundation of China[41876175] ; National Key Research and Development Project of China[2018YFD0900504] ; Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ0302-2] ; Distinguished Young Scientists Research Fund of Key Laboratory of Experimental Marine Biology, Chinese Academy of Sciences[KLEMB-DYS03] ; Taishan Scholar Program of Shandong Province
WOS研究方向	Immunology
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号	WOS:000596699100002
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/169374]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Sun, Li
作者单位	1.Chinese Acad Sci, CAS Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China 2.Chinese Acad Sci, CAS Ctr Ocean Megasci, Qingdao, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Hainan Univ, State Key Lab Marine Resource Utilizat South Chin, Haikou, Hainan, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Shuai,Zhou, Zhi,Sun, Yuanyuan,et al. Coral gasdermin triggers pyroptosis[J]. SCIENCE IMMUNOLOGY,2020,5(54):10.
APA	Jiang, Shuai,Zhou, Zhi,Sun, Yuanyuan,Zhang, Tengfei,&Sun, Li.(2020).Coral gasdermin triggers pyroptosis.SCIENCE IMMUNOLOGY,5(54),10.
MLA	Jiang, Shuai,et al."Coral gasdermin triggers pyroptosis".SCIENCE IMMUNOLOGY 5.54(2020):10.