Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480

doi:10.3390/md18070339

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480
	Meng, Ling-Hong 1,2; Li, Xiao-Ming 1,2; Li, Hong-Lei 1,2; Wang, Bin-Gui 1,2,3
刊名	MARINE DRUGS
	2020-07-01
卷号	18 期号:7 页码:10
关键词	Penicillium chermesinum Penicillium bilaiae co-culture secondary metabolites antimicrobial activity
DOI	10.3390/md18070339
通讯作者	Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
英文摘要	The co-cultivation of two or more different microbial strains in one culture vessel was supposed to be a viable experimental approach for enhancing the diversity of the compounds produced. Two new meroterpenoid derivatives, chermebilaenes A (1) and B (2), together with three known sesquiterpenoids, sesquicaranoic acid B (3), cyclonerodiol (4) and bisabol-l-on-13-sauremethylester (5), were characterized from a co-culture of the marine-derived fungal isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480. Neither fungus produced these compounds when cultured alone under the same conditions. Compound1represents an unprecedented acorane-type sesquiterpene hybridized with an octadecadienoic acid skeleton. The structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were assumed on the basis of acidic hydrolysis combined with modified Mosher's method and electronic circular dichroism (ECD) calculations. Compound1showed potent inhibitory activities againstCeratobasidium cornigerumandEdwardsiella tarda.
资助项目	Natural Science Foundation of China[31600267] ; Natural Science Foundation of China[41976090] ; Qingdao National Laboratory for Marine Science and Technology[YQ2018NO08] ; project of Qingdao Science and Technology Bureau[18-2-2-59-jch] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250] ; Taishan Scholar Project from Shandong Province
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	MDPI
WOS记录号	WOS:000554187500001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/168078]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Meng, Ling-Hong; Wang, Bin-Gui
作者单位	1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Meng, Ling-Hong,Li, Xiao-Ming,Li, Hong-Lei,et al. Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480[J]. MARINE DRUGS,2020,18(7):10.
APA	Meng, Ling-Hong,Li, Xiao-Ming,Li, Hong-Lei,&Wang, Bin-Gui.(2020).Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480.MARINE DRUGS,18(7),10.
MLA	Meng, Ling-Hong,et al."Chermebilaenes A and B, New Bioactive Meroterpenoids from Co-Cultures of Marine-Derived Isolates ofPenicillium bilaiaeMA-267 andPenicillium chermesinumEN-480".MARINE DRUGS 18.7(2020):10.