Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299

doi:10.1016/j.bioorg.2020.103950

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	Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299
	Zhang, Fan-Zhong 1,3; Li, Xiao-Ming 1,3; Meng, Ling-Hong 1,3; Wang, Bin-Gui 1,2,3
刊名	BIOORGANIC CHEMISTRY
	2020-08-01
卷号	101 页码:6
关键词	Mangrove-derived Endophytic fungus Cladosporium cladosporioides Sulfur substitution Biogenetic pathway Antimicrobial activities
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2020.103950
通讯作者	Meng, Ling-Hong(menglh@ms.qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
英文摘要	A simple but previously undescribed macrolide with unprecedented bicyclo 5/9 ring system, namely, clado-cladosin A (1), along with two new sulfur-containing macrolides, namely, thiocladospolides F and G (2 and 3), were characterized from the mangrove-derived endophytic fungus Cladosporium cladosporioides MA-299. The structures of these compounds were established on the basis of spectroscopic interpretation, and the absolute configurations of compounds 1-3 were determined by X-ray crystallographic analysis, Mosher's method, and by a biogenetic point of view. The possible biogenetic pathway for compounds 1-3 as well as their congeners thiocladospolides A-D and pandangolide 3 was proposed, providing a role in distinguishing the position of sulfur substitution in thiomacrolides. Compounds 1-3 were evaluated for antimicrobial activities against human-, aquatic-, and plant-pathogenic microbes.
资助项目	National Natural Science Foundation of China[81673351] ; National Natural Science Foundation of China[31600267] ; Natural Science Foundation of Shandong Province[ZR2016BQ17] ; Taishan Scholar project from Shandong province
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000552629800012
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/168032]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Meng, Ling-Hong; Wang, Bin-Gui
作者单位	1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,et al. Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299[J]. BIOORGANIC CHEMISTRY,2020,101:6.
APA	Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,&Wang, Bin-Gui.(2020).Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299.BIOORGANIC CHEMISTRY,101,6.
MLA	Zhang, Fan-Zhong,et al."Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299".BIOORGANIC CHEMISTRY 101(2020):6.