Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection

doi:10.1016/j.fsi.2019.12.022

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection
	Ji, Liqin 2,3,4,5; Sun, Guoxiang 4; Li, Xian 2,4,5; Liu, Ying 1,5
刊名	FISH & SHELLFISH IMMUNOLOGY
	2020-03-01
卷号	98 页码:87-99
关键词	beta-glucan Rainbow trout Transcriptome Spleen Aeromonas salmonicida
ISSN号	1050-4648
DOI	10.1016/j.fsi.2019.12.022
通讯作者	Liu, Ying(yingliu@dlou.edu.cn)
英文摘要	To study the mechanism of beta-glucan in immune protection, rainbow trout were fed diets with or without 0.2% beta-glucan for 42 days and then infected with Aeromonas sabnonicida. After that, spleen tissues were sampled on 4-and 6-days post infection (dpi). Transcriptome analysis was compared between control group (CG, without beta-glucan addition) and 0.2% beta-glucan group (BG). In CG vs BG, 378 and 406 DEGs were identified on 4 dpi and 6 dpi respectively; furthermore, 46 DEGs were shared on 4 dpi and 6 dpi, enriching in GO terms, such as complement activation, inflammatory response, and metabolic process. KEGG pathway analysis revealed that some DEGs in CG vs BG were involved in immune or metabolic signaling pathways such as complement and coagulation cascades, toll-like receptor signaling pathway, NF-kappa B signaling pathway, antigen processing and presentation, and platelet activation on 4 or 6 dpi. DEGs, such as fgg, fgb, f5, c9, c3, c5, dry, and myd88, were analyzed in CG vs BG on 4 dpi and 6 dpi, implying their potential roles in beta-glucan-modulated immunity. These results are beneficial to understand the mechanism of beta-glucan in resisting bacteria in fish.
资助项目	National Key Technologies RD Program[2017YFB0404000] ; Key R&D Program of Guangdong Province[2019B020215001] ; National Natural Science Foundation of China[31672673] ; Key Technologies R&D Program of Shandong Province[2018GHY115031]
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种	英语
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号	WOS:000516880900010
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/167117]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Liu, Ying
作者单位	1.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266235, Peoples R China
推荐引用方式 GB/T 7714	Ji, Liqin,Sun, Guoxiang,Li, Xian,et al. Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection[J]. FISH & SHELLFISH IMMUNOLOGY,2020,98:87-99.
APA	Ji, Liqin,Sun, Guoxiang,Li, Xian,&Liu, Ying.(2020).Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection.FISH & SHELLFISH IMMUNOLOGY,98,87-99.
MLA	Ji, Liqin,et al."Comparative transcriptome analysis reveals the mechanism of beta-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection".FISH & SHELLFISH IMMUNOLOGY 98(2020):87-99.